D5676
N -去甲基氯氮平
5-HT2 serotonin receptor antagonist, powder
别名:
8-氯-11-哌嗪基-5H-二苯并 [b,e] \ [1,4] 二氮嗪, 去甲氯氮平, 去甲甲基氯氮平
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关于此项目
经验公式（希尔记法）:
C17H17ClN4
化学文摘社编号:
分子量:
312.80
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
N -去甲基氯氮平,
表单
powder
质量水平
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
SMILES字符串
Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
InChI
1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key
JNNOSTQEZICQQP-UHFFFAOYSA-N
基因信息
human ... KCNH1(3756)
相关类别
应用
本文以 N-去甲基氯氮平为标准，对中国难治性精神分裂症患者的氯氮平血药浓度进行了定量测定。
生化/生理作用
N-去甲基氯氮平是毒蕈碱型乙酰胆碱受体的激动剂，已知具有抗精神病作用。它通过拮抗突触内 GABA（γ-氨基丁酸）受体阻止突触传递。
氯氮平的主要代谢产物；有效的 5-HT 2 5-羟色胺受体拮抗剂和克隆的 5-HT 6 和 5-HT 7 5-羟色胺受体的配体。也是 M 1 毒蕈碱受体的变构增效剂。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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