D5676
N -去甲基氯氮平
5-HT2 serotonin receptor antagonist, powder
别名:
8-氯-11-哌嗪基-5H-二苯并 [b,e] \ [1,4] 二氮嗪, 去甲氯氮平, 去甲甲基氯氮平
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关于此项目
经验公式（希尔记法）:
C17H17ClN4
化学文摘社编号:
分子量:
312.80
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Quality level:
产品名称
N -去甲基氯氮平,
SMILES string
Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
InChI
1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key
JNNOSTQEZICQQP-UHFFFAOYSA-N
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
Quality Level
Gene Information
human ... KCNH1(3756)
相关类别
Application
本文以 N-去甲基氯氮平为标准，对中国难治性精神分裂症患者的氯氮平血药浓度进行了定量测定。
Biochem/physiol Actions
N-去甲基氯氮平是毒蕈碱型乙酰胆碱受体的激动剂，已知具有抗精神病作用。它通过拮抗突触内 GABA（γ-氨基丁酸）受体阻止突触传递。
氯氮平的主要代谢产物；有效的 5-HT 2 5-羟色胺受体拮抗剂和克隆的 5-HT 6 和 5-HT 7 5-羟色胺受体的配体。也是 M 1 毒蕈碱受体的变构增效剂。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of chromatography, 622(1), 39-46 (1993-12-08)
A fully automated method for determination of clozapine and desmethylclozapine in human serum using high-performance liquid chromatography was developed. On-line solid-phase extraction was performed on an exchangeable cyanopropyl cartridge. The analytes were eluted with a methanol-ammonium acetate buffer mobile phase
Vincent Bessonneau et al.
Environmental health perspectives, 125(7), 077014-077014 (2017-07-27)
There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide association studies (EWAS) are being conducted to investigate associations between a myriad
Cyrille Sur et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(23), 13674-13679 (2003-11-05)
The molecular and neuronal substrates conferring on clozapine its unique and superior efficacy in the treatment of schizophrenia remain elusive. The interaction of clozapine with many G protein-coupled receptors is well documented but less is known about its biologically active
Frontiers in Clinical Drug Research- Central Nervous System, 19-19 (2013)
Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients
Wong JO, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(2), 251-264 (2006)
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