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D5676

N -去甲基氯氮平

Name: <I>N </I>-去甲基氯氮平
Brand: SIGMA

5-HT2 serotonin receptor antagonist, powder

别名:

8-氯-11-哌嗪基-5H-二苯并 [b,e] \ [1,4] 二氮嗪, 去甲氯氮平, 去甲甲基氯氮平

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₇ClN₄

化学文摘社编号:

6104-71-8

分子量:

312.80

UNSPSC Code:

12352200

PubChem Substance ID:

24893957

NACRES:

NA.77

MDL number:

MFCD00210189

Form:

powder

Quality level:

200

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产品名称

N -去甲基氯氮平,

form

powder

Quality Level

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES string

Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4

InChI

1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2

InChI key

JNNOSTQEZICQQP-UHFFFAOYSA-N

Gene Information

human ... KCNH1(3756)

Application

本文以 N-去甲基氯氮平为标准，对中国难治性精神分裂症患者的氯氮平血药浓度进行了定量测定。

Biochem/physiol Actions

N-去甲基氯氮平是毒蕈碱型乙酰胆碱受体的激动剂，已知具有抗精神病作用。它通过拮抗突触内 GABA（γ-氨基丁酸）受体阻止突触传递。

氯氮平的主要代谢产物；有效的 5-HT ₂ 5-羟色胺受体拮抗剂和克隆的 5-HT ₆ 和 5-HT ₇ 5-羟色胺受体的配体。也是 M ₁ 毒蕈碱受体的变构增效剂。

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332,H315,H319,H335

pcodes

P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000522917

0000445532

0000436119

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全球贸易项目编号

货号	GTIN
D5676-5MG	04061832090511
D5676-10MG	04061833586631

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