D5767
2,2′-二硫二吡啶
powder
别名:
2,2′-二吡啶基二硫醚
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关于此项目
经验公式（希尔记法）:
C10H8N2S2
化学文摘社编号:
分子量:
220.31
UNSPSC Code:
12352112
NACRES:
NA.26
PubChem Substance ID:
EC Number:
218-343-1
Beilstein/REAXYS Number:
154629
MDL number:
Application
2,2′-二硫二吡啶用于单链抗体还原链间二硫键的重建。可作为 T 细胞杂交瘤细胞培养的介质成分和巯基交联剂。
Biochem/physiol Actions
2,2′-二硫二吡啶介导单元间二硫键交联。与碳亲核体相互作用生成硫代吡啶衍生物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.
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Oncogene (2000)
Human T cells resistant to complement lysis by bivalent antibody can be efficiently lysed by dimers of monovalent antibody
Nielsen SU and Routledge EG
Blood, 100(12), 4067-4073 (2002)
Peptide-unit assembling using disulfide cross-linking: a new approach for construction of protein models
Futaki S and Kitagawa K
Tetrahedron Letters, 35(8), 1267-1270 (1994)
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2005)
Mark L Dallas et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(5), 1519-1530 (2011-01-21)
Oxidative stress induces neuronal apoptosis and is implicated in cerebral ischemia, head trauma, and age-related neurodegenerative diseases. An early step in this process is the loss of intracellular K(+) via K(+) channels, and evidence indicates that K(v)2.1 is of particular
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