D5794
二酰甘油激酶抑制剂II
solid
别名:
3-[2-[4-(双(4-氟苯基)亚甲基)-1-哌啶基]乙基]-2,3-二氢-2-硫代-4(1H)-喹唑啉酮, R59949
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关于此项目
经验公式（希尔记法）:
C28H25F2N3OS
化学文摘社编号:
分子量:
489.58
MDL编号:
UNSPSC代码:
41106300
PubChem化学物质编号:
NACRES:
NA.77
生物来源
synthetic (organic)
方案
≥97% (HPLC)
表单
solid
颜色
pale yellow
mp
228-230 °C
溶解性
0.1 M HCl: slightly soluble
0.1 M NaOH: slightly soluble
DMSO: soluble
H2O: insoluble
ethanol: soluble
ethyl acetate: soluble
储存温度
−20°C
SMILES字符串
Fc1ccc(cc1)\C(=C2\CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5
InChI
1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
InChI key
ZCNBZFRECRPCKU-UHFFFAOYSA-N
相关类别
应用
甘油二酯激酶抑制剂II可用于确定嵌合抗原受体 (CAR) 改造的细胞毒性T细胞的肿瘤诱导抑制。它还用于诱导T细胞急性淋巴细胞白血病中的pAkt和PKR样细胞外信号调节激酶 (pErk) 信号。
生化/生理作用
二酰基甘油激酶抑制剂。抑制红细胞膜中[38P]1-油酰基-2-乙酰甘油基-3-磷酸（OAPA）的形成：IC50 = 3.3 μM。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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