D5919
二酰基甘油激酶抑制剂I
solid
别名:
6-[2-[4-[(4-氟苯基)苯基亚甲基]-1-哌啶基]乙基]-7-甲基-5H-噻唑基-[3,2-a]-嘧啶-5-酮, R59022
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C27H26FN3OS
化学文摘社编号:
分子量:
459.58
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106300
MDL number:
InChI
1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3
SMILES string
CC1=C(CCN2CCC(\CC2)=C(\c3ccccc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
InChI key
MFVJXLPANKSLLD-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
solid
color
pale yellow
solubility
0.1 M HCl: slightly soluble, 0.1 M NaOH: slightly soluble, DMSO: soluble, H2O: insoluble, ethanol: soluble, ethyl acetate: soluble
storage temp.
−20°C
Quality Level
正在寻找类似产品? 访问 产品对比指南
相关类别
General description
二酰基甘油激酶抑制剂I可防止异物巨细胞（FBGC）的形成。 它可抑制二酰基甘油磷酸化为磷脂酸。 二酰基甘油激酶抑制剂I可充当血清素（5-HT）受体（5-HTR）拮抗剂。它可刺激神经元细胞系NG108-15的凋亡和自噬。
Application
二酰基甘油激酶抑制剂I已被用作抑制剂用于使用高世代人类CAR（嵌合抗原受体）T细胞研究T细胞功能的抑制作用。
Biochem/physiol Actions
二酰基甘油激酶抑制剂。抑制红细胞膜中[38P]1-油酰基-2-乙酰甘油基-3-磷酸（OAPA）的形成：IC50 = 3.3 μM。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ana M Laxalt et al.
The Journal of biological chemistry, 282(29), 21160-21168 (2007-05-11)
Nitric Oxide (NO) is a second messenger related to development and (a)biotic stress responses in plants. We have studied the role of NO in signaling during plant defense responses upon xylanase elicitation. Treatment of tomato cell cultures with the fungal
Yoshihiko Kito et al.
American journal of physiology. Gastrointestinal and liver physiology, 298(5), G755-G763 (2010-02-20)
The relaxant effects of Rikkunshi-to (TJ-43), a gastroprotective herbal medicine, on rat gastric fundus were investigated. Experiments were carried out using standard tension and intracellular microelectrode recording techniques. During contraction induced by enprostil (0.5 microM), a prostaglandin E(2) analog, TJ-43
Amy K McNally et al.
The American journal of pathology, 163(3), 1147-1156 (2003-08-26)
Multinucleated foreign body giant cells (FBGCs) form by monocyte-derived macrophage fusion on implanted biomedical devices and are believed to mediate oxidative damage to biomaterial surfaces. Our in vitro system of human macrophage culture and interleukin (IL)-4-induced FBGC formation was developed
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
Moon EK, et al.
Clinical Cancer Research, 197-201 (2014)
Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid
Packham MA, et al.
The Biochemical Journal, 290(3), 849-856 (1993)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持