D5943
2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide
≥98% (HPLC), solid
别名:
Flt-3 inhibitor
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关于此项目
经验公式（希尔记法）:
C18H20N2O4S
化学文摘社编号:
分子量:
360.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
InChI key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
SMILES string
COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O
InChI
1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
assay
≥98% (HPLC)
form
solid
storage condition
protect from light, under inert gas
color
white to off-white
solubility
H2O: <2 mg/mL, DMSO: ~8 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Flt-3 (fms-related tyrosine kinase 3) inhibitor
Features and Benefits
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Raymond J Patch et al.
Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship
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