D5943
2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide
≥98% (HPLC), solid
别名:
Flt-3 inhibitor
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关于此项目
经验公式（希尔记法）:
C18H20N2O4S
化学文摘社编号:
分子量:
360.43
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
under inert gas
颜色
white to off-white
溶解性
H2O: <2 mg/mL
DMSO: ~8 mg/mL
储存温度
−20°C
SMILES字符串
COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O
InChI
1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChI key
FSPQCTGGIANIJZ-UHFFFAOYSA-N
生化/生理作用
Flt-3 (fms-related tyrosine kinase 3) inhibitor
特点和优势
This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Raymond J Patch et al.
Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship
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