D6035
达舒平 磷酸盐
别名:
双异丙吡胺
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关于此项目
线性分子式:
C21H29N3O · H3PO4
CAS Number:
分子量:
437.47
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
SMILES字符串
OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C
InChI
1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
InChI key
CGDDQFMPGMYYQP-UHFFFAOYSA-N
基因信息
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相关类别
应用
Disopyramide phosphate salt has been used as an internal standard for plasma sample analysis by mass spectrometry. It might be used as a test compound in a teratogenicity study.
生化/生理作用
IA 类抗心律失常药；钠通道阻断剂
Disopyramide is found to stabilize the cell membrane by altering the action potential. It might act as an antiarrhythmic agent.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
0
Drugs for Pregnant and Lactating Women, 252-338 (2009)
Akihito Yamashita et al.
The Journal of toxicological sciences, 39(3), 453-464 (2014-05-23)
The zebrafish has been considered as a suitable animal model for drug discovery, especially for evaluation of the teratogenicity, due to their small size, rapid development, transparency, and developmental similarities to mammalian development. These features of zebrafish make it possible
Anthony A Fossa et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 828-833 (2002-07-20)
QT interval prolongation of the electrocardiogram has been associated with the occurrence of life-threatening fatal ventricular arrhythmias. To understand the relationship between preclinical cardiac conduction assessment to clinical outcome, comparisons of free (unbound)-plasma drug concentrations and their associated effects in
Dan Musat et al.
Progress in cardiovascular diseases, 54(6), 535-542 (2012-06-13)
Pharmacologic therapy is the first line approach to relieve symptoms in obstructive hypertrophic cardiomyopathy. There are no randomized trials to evaluate their effect on prognosis. Gradient reduction by surgical septal myectomy is associated with excellent prognosis, but not all patients
Enrique Ochoa-Aranda et al.
Journal of AOAC International, 94(2), 537-542 (2011-05-14)
A micellar liquid chromatography (MLC) method using a C18 column was developed to determine three antiarrhythmic drugs--disopyramide, lidocaine, and quinidine--that are most usually monitored in serum samples. After the application of an interpretative strategy for optimization of sodium dodecyl sulfate
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