D6135
Distamycin A hydrochloride from Streptomyces distallicus
≥90% (TLC)
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经验公式（希尔记法）:
C22H27N9O4 · HCl
化学文摘社编号:
分子量:
517.97
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
229-505-6
MDL number:
SMILES string
Cl.Cn1cc(NC=O)cc1C(=O)Nc2cc(C(=O)Nc3cc(C(=O)NCCC(N)=N)n(C)c3)n(C)c2
assay
≥90% (TLC)
mode of action
DNA synthesis | interferes
storage temp.
−20°C
Biochem/physiol Actions
Reported to specifically inhibit the initiation of RNA synthesis.
Vivian Chagas da Silveira et al.
Journal of inorganic biochemistry, 105(12), 1692-1703 (2011-11-22)
Previous studies on copper(II) complexes with oxindole-Schiff base ligands have shown their potential antitumor activity towards different cells, inducing apoptosis through a preferential attack to DNA and/or mitochondria. Herein, we better characterize the interactions between some of these copper(II) complexes
Mateus Mondin et al.
Genome, 54(9), 718-726 (2011-08-26)
Most Crotalaria species display a symmetric karyotype with 2n = 16, but 2n = 14 is found in Chrysocalycinae subsection Incanae and 2n = 32 in American species of the section Calycinae. Seven species of the sections Chrysocalycinae, Calycinae, and
Mariko Asagi et al.
Biophysical chemistry, 149(1-2), 34-39 (2010-04-17)
Distamycin A (Dst) is an antibiotic which binds to the minor groove of double-stranded DNA at A/T-rich regions. We have examined the affinity and mode of Dst binding to DNA duplexes containing a conserved A/T core and variable terminal A/T
Gaetano Marverti et al.
Amino acids, 42(2-3), 641-653 (2011-08-05)
Acquired resistance to cisplatin (cDDP) is a multifactorial process that represents one of the main problems in ovarian cancer therapy. Distamycin A is a minor groove DNA binder whose toxicity has limited its use and prompted the synthesis of derivatives
Terri G Edwards et al.
Antiviral research, 91(2), 177-186 (2011-06-15)
Human papillomavirus (HPV) causes cervical cancer and other hyperproliferative diseases. There currently are no approved antiviral drugs for HPV that directly decrease viral DNA load and that have low toxicity. We report the potent anti-HPV activity of two N-methylpyrrole-imidazole polyamides
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