D6413
Diloxanide furoate
别名:
2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester
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关于此项目
经验公式（希尔记法）:
C14H11Cl2NO4
化学文摘社编号:
分子量:
328.15
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
223-108-1
MDL number:
InChI key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
InChI
1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
SMILES string
CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1
antibiotic activity spectrum
parasites
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E A Gadkariem et al.
Farmaco (Societa chimica italiana : 1989), 59(4), 323-329 (2004-04-15)
The degradation of the amoebicide diloxanide furoate in alkaline medium at different temperatures was investigated using both a spectrophotometric and a developed HPLC method. In solutions, the drug was found to undergo decomposition, i.e., temperature and pH dependent. The pH-rate
Julieta B Monteiro et al.
International journal of pharmaceutics, 267(1-2), 93-100 (2003-11-07)
In this study, we investigated the susceptibility to enzymatic and alkaline hydrolysis of diloxanide furoate (DF) and its cyclodextrin inclusion complexes, in aqueous solution. The cyclodextrins (CDs) utilized were beta-cyclodextrin (beta-CD), (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) and (2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD). All cyclodextrins studied provided
Asteria Luzardo Álvarez et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 215-227 (2012-06-20)
We present a new strategy to suppress the attachment of Cryptosporidium parvum to the enterocytes cell surface by bioadhesive microspheres. An optimized microsphere system based on chitosan/poly(vinyl alcohol) was prepared by experimental design for the delivery of Diloxanide Furoate-cyclodextrin complex.
Alaa El-Gindy et al.
Journal of AOAC International, 93(2), 536-548 (2010-05-20)
Three methods were developed for the determination of two ternary mixtures containing drotaverine hydrochloride (DR) with caffeine and paracetamol (mixture 1) and DR with metronidazole and diloxanide furoate (mixture 2). The first method depends on HPLC separation on an RP
Adel Mishal et al.
Journal of pharmaceutical and biomedical analysis, 39(3-4), 819-823 (2005-08-02)
A selective, precise and accurate isocratic RP-HPLC method has been developed and validated for the simultaneous determination of metronidazole benzoate (MB), diloxanide furoate (DF), methyl paraben (MPn) and propyl paraben (PPn) in suspension. The cis/trans isomerization phenomenon for DF has
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