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Merck
CN

D7000

Sigma-Aldrich

醋酸去氧皮质酮

synthetic (organic), ≥98% (HPLC), mineralocorticoid and glucocorticoid, powder

别名:

11-去氧皮质酮乙酸酯, 21-乙酰氧基孕甾-4-烯-3,20-二酮, 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯, 21-羟基孕酮-21-乙酸酯, DOC 乙酸酯, 乙酸脱氧肾上腺皮质固酮, 孕甾-4-烯-21-醇-3,20-二酮-21-醋酸酯, 脱氧皮质酮醋酸酯

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关于此项目

经验公式（希尔记法）:
C23H32O4
CAS Number:
56-47-3
分子量:
372.50
Beilstein:
2570798
EC 号:
200-275-9
MDL编号:
MFCD00003660
UNSPSC代码:
12352200
PubChem化学物质编号:
24894065
NACRES:
NA.77

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Product Name

醋酸去氧皮质酮,

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

方案

≥98% (HPLC)

表单

powder

溶解性

H2O: insoluble
acetone: soluble (1 in 30)
alcohol: soluble (1 in 50)
chloroform: freely soluble
dioxane: slightly soluble
vegetable oils: slightly soluble

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

基因信息

human ... NR3C2(4306)

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相关类别

一般描述

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

应用

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000181090
0000181090
0000395632
0000340896
0000211306

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The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function.
Vinson GP
The Journal of Endocrinology, 211(1), 3-16 (2011)
Douglas Jackson et al.
Molecules (Basel, Switzerland), 23(7) (2018-06-23)
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study
(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats
Jackson D, et al.
Molecules (Basel), 23(7), 1511-1511 (2018)
Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction
Chimini JS, et al.
Basic and Clinical Pharmacology and Toxicology (2018)
Cassandra Kapsa et al.
Journal of forensic sciences, 65(6), 1961-1967 (2020-08-19)
The purpose of this research is to determine if latent fingerprints deposited on the exterior glass surfaces of vehicles, then covered in debris, can be recovered. Past research used liquid latex to lift soot to recover trace evidence. Recently, liquid
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