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D7000

醋酸去氧皮质酮

Name: 醋酸去氧皮质酮
Brand: SIGMA

synthetic (organic), ≥98% (HPLC), mineralocorticoid and glucocorticoid, powder

别名:

11-去氧皮质酮乙酸酯, 21-乙酰氧基孕甾-4-烯-3,20-二酮, 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯, 21-羟基孕酮-21-乙酸酯, DOC 乙酸酯, 乙酸脱氧肾上腺皮质固酮, 孕甾-4-烯-21-醇-3,20-二酮-21-醋酸酯, 脱氧皮质酮醋酸酯

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关于此项目

经验公式（希尔记法）:

C₂₃H₃₂O₄

化学文摘社编号:

56-47-3

分子量:

372.50

NACRES:

NA.77

PubChem Substance ID:

24894065

UNSPSC Code:

12352200

EC Number:

200-275-9

MDL number:

MFCD00003660

Beilstein/REAXYS Number:

2570798

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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属性

产品名称

醋酸去氧皮质酮,

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

H₂O: insoluble, acetone: soluble (1 in 30), alcohol: soluble (1 in 50), chloroform: freely soluble, dioxane: slightly soluble, vegetable oils: slightly soluble

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

Gene Information

human ... NR3C2(4306)

说明

General description

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

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存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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(-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats.

Douglas Jackson et al.

Molecules (Basel, Switzerland), 23(7) (2018-06-23)

(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study

Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction

Chimini JS, et al.

Basic and Clinical Pharmacology and Toxicology (2018)

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function.

Vinson GP

The Journal of Endocrinology, 211(1), 3-16 (2011)

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全球贸易项目编号

货号	GTIN
D7000-5G	04061835512447
D7000-25G	04061833588062
D7000-1G	04061833588055