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Merck
CN

D7000

醋酸去氧皮质酮

synthetic (organic), ≥98% (HPLC), mineralocorticoid and glucocorticoid, powder

别名:

11-去氧皮质酮乙酸酯, 21-乙酰氧基孕甾-4-烯-3,20-二酮, 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯, 21-羟基孕酮-21-乙酸酯, DOC 乙酸酯, 乙酸脱氧肾上腺皮质固酮, 孕甾-4-烯-21-醇-3,20-二酮-21-醋酸酯, 脱氧皮质酮醋酸酯

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关于此项目

经验公式（希尔记法）:
C23H32O4
化学文摘社编号:
56-47-3
分子量:
372.50
NACRES:
NA.77
PubChem Substance ID:
24894065
UNSPSC Code:
12352200
EC Number:
200-275-9
MDL number:
MFCD00003660
Beilstein/REAXYS Number:
2570798

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产品名称

醋酸去氧皮质酮,

InChI key

VPGRYOFKCNULNK-ACXQXYJUSA-N

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

H2O: insoluble
acetone: soluble (1 in 30)
alcohol: soluble (1 in 50)
chloroform: freely soluble
dioxane: slightly soluble
vegetable oils: slightly soluble

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... NR3C2(4306)

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相关类别

Application

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

General description

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000181090
0000181090
0000395632
0000340896
0000211306

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Rafael Soares Lindoso et al.
Molecular therapy. Methods & clinical development, 16, 63-77 (2019-12-25)
Hypertension is a long-term condition that can increase organ susceptibility to insults and lead to severe complications such as chronic kidney disease (CKD). Extracellular vesicles (EVs) are cell-derived membrane structures that participate in cell-cell communication by exporting encapsulated molecules to
Cassandra Kapsa et al.
Journal of forensic sciences, 65(6), 1961-1967 (2020-08-19)
The purpose of this research is to determine if latent fingerprints deposited on the exterior glass surfaces of vehicles, then covered in debris, can be recovered. Past research used liquid latex to lift soot to recover trace evidence. Recently, liquid
Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation
Porcu P, et al.
PLoS ONE, 6(4), e18405-e18405 (2011)
Douglas Jackson et al.
Molecules (Basel, Switzerland), 23(7) (2018-06-23)
(−)-Epicatechin (E) is a flavanol found in green tea and cocoa and has been shown to attenuate tumour necrosis factor alpha (TNF-α)-mediated inflammation, improve nitric oxide levels, promote endothelial nitric oxide synthase (eNOS) activation and inhibit NADPH oxidase. This study
The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function.
Vinson GP
The Journal of Endocrinology, 211(1), 3-16 (2011)
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