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Merck
CN

D7006

二氢叶酸

≥90%

别名:

7,8-二氢蝶酰- L -谷氨酸, FAH2, 二氢蝶酰- L -谷氨酸

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关于此项目

经验公式（希尔记法）:
C19H21N7O6
化学文摘社编号:
4033-27-6
分子量:
443.41
UNSPSC Code:
12352106
NACRES:
NA.79
PubChem Substance ID:
24894068
MDL number:
MFCD00083619
Beilstein/REAXYS Number:
69017
Assay:
≥90%
Form:
powder

主要文件

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产品名称

二氢叶酸, ≥90%

InChI

1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

SMILES string

NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1

InChI key

OZRNSSUDZOLUSN-LBPRGKRZSA-N

biological source

synthetic (organic)

assay

≥90%

form

powder

color

light yellow to dark yellow-orange

storage temp.

−20°C

Quality Level

200

Gene Information

human ... DHFRP1(573971)
mouse ... Dhfr(13361)

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相关类别

Application

二氢叶酸用于心肌黄酶偶联测定，测定二氢叶酸还原酶（DHFR）活性。它也用作测定缓冲液成分，确定二氢叶酸还原酶（DHFR）的活性。

Biochem/physiol Actions

叶酸 (FA) 和二氢叶酸 (FAH2) 是二氢叶酸还原酶 (s) 的底物，将其还原成四氢叶酸 (THF)，后者支持“一碳”转移。嘌呤、胸苷酸和各种氨基酸的从头合成以及翻译后甲基化（表观遗传学）需要四氢叶酸。

General description

通过二氢叶酸还原酶 (DHFR) 将膳食叶酸转化为四氢叶酸的中间产物。在细菌中，二氢叶酸是 7,8-二氢蝶酸由二氢叶酸合成酶生成。

Packaging

密封安瓿。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000516250
0000516250
0000490236
0000490236
0000493087

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