D7071
达泊西汀 盐酸盐
≥98% (HPLC)
别名:
(S)-(+)-N,N-二甲基-1-苯基-3-(1-萘氧基)丙胺盐酸盐, (S)-(+)-N,N-二甲基-a-[2-(萘氧基)乙基]苯甲胺盐酸盐，LY-210448 盐酸盐
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关于此项目
经验公式（希尔记法）:
C21H23NO · HCl
化学文摘社编号:
分子量:
341.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +125 to +135°, c = 1 in methanol
storage condition
desiccated
color
white
solubility
DMSO: ≥20 mg/mL
originator
Eli Lilly
storage temp.
room temp
SMILES string
Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3
InChI
1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
InChI key
IHWDIQRWYNMKFM-BDQAORGHSA-N
Gene Information
human ... SLC6A4(6532)
General description
达泊西汀（(+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐）的结构类似于氟西汀。
Biochem/physiol Actions
达泊西汀可阻断重组Kv4.3电压门控钾通道。已确认为安全的治疗药物。
有效的选择性5-羟色胺再摄取抑制剂（SSRI）；用于治疗早泄
有效的选择性SSRI
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
W J G Hellstrom
International journal of clinical practice, 65(1), 16-26 (2010-12-16)
Current and upcoming treatment options for premature ejaculation (PE) are of global clinical interest. In 2008, the International Society for Sexual Medicine published an evidence-based definition for PE. While there are no US Food and Drug Administration-approved therapies for PE
Chris G McMahon et al.
The journal of sexual medicine, 8(2), 524-539 (2010-11-10)
Dapoxetine has been evaluated for the on-demand treatment of premature ejaculation (PE) in five phase 3 studies in various populations worldwide and has recently been approved in several countries. To present integrated efficacy and safety data from phase 3 trials
Imju Jeong et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(7), 707-716 (2012-04-28)
The effects of dapoxetine were examined on cloned Kv1.5 channels stably expressed in Chinese hamster ovary cells using the whole-cell patch clamp technique. Dapoxetine decreased the peak amplitude of Kv1.5 currents and accelerated the decay rate of current inactivation in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7071-50MG | 04061833588185 |
| D7071-10MG | 04061833588178 |