D7071
达泊西汀 盐酸盐
≥98% (HPLC)
别名:
(S)-(+)-N,N-二甲基-1-苯基-3-(1-萘氧基)丙胺盐酸盐, (S)-(+)-N,N-二甲基-a-[2-(萘氧基)乙基]苯甲胺盐酸盐，LY-210448 盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H23NO · HCl
化学文摘社编号:
分子量:
341.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
达泊西汀 盐酸盐, ≥98% (HPLC)
InChI
1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
SMILES string
Cl.CN(C)[C@@H](CCOc1cccc2ccccc12)c3ccccc3
InChI key
IHWDIQRWYNMKFM-BDQAORGHSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +125 to +135°, c = 1 in methanol
storage condition
desiccated
color
white
solubility
DMSO: ≥20 mg/mL
originator
Eli Lilly
storage temp.
room temp
Quality Level
Gene Information
human ... SLC6A4(6532)
Biochem/physiol Actions
有效的选择性5-羟色胺再摄取抑制剂（SSRI）；用于治疗早泄
有效的选择性SSRI
达泊西汀可阻断重组Kv4.3电压门控钾通道。已确认为安全的治疗药物。
Features and Benefits
该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
General description
达泊西汀（(+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐）的结构类似于氟西汀。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sheridan M Hoy et al.
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Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with premature ejaculation. In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60
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Selective serotonin reuptake inhibitors (SSRIs) have an inhibitory effect on various ion channels including Ca
Kate Hutchinson et al.
Drug safety, 35(5), 359-372 (2012-03-29)
Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop
Hartmut Porst et al.
The journal of sexual medicine, 7(6), 2231-2242 (2010-04-24)
Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. To
Dapoxetine: a new option in the medical management of premature ejaculation
McMahon CG
Therapeutic Advances in Urology, 4(5), 233-251 (2012)
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