Quality Level
assay
≥99%
form
powder
mp
254-255 °C (dec.) (lit.)
SMILES string
OC(=O)[C@@H]1CC(=O)NC(=O)N1
InChI
1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
InChI key
UFIVEPVSAGBUSI-REOHCLBHSA-N
Application
L-二氢乳清酸(DHO)用作二氢乳清酸脱氢酶(DHODH)检测的底物。
Biochem/physiol Actions
L-二氢乳清酸(DHO)是二氢乳清酸脱氢酶(DHODH)的底物，而DHODH是一种从头合成嘧啶的酶。抑制剂对DHOH的抑制作用会导致上游代谢物DHO大量积累和尿苷水平下降。因此，DHO和尿苷可作为嘧啶合成的生物标志物，用于临床开发DHOH抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Feng Yin et al.
Journal of pharmaceutical and biomedical analysis, 192, 113669-113669 (2020-10-30)
Uridine and L-dihydroorotate (DHO) are important intermediates of de novo as well as salvage pathways for the biosynthesis of pyrimidines, which are the building blocks of nucleic acids - DNA and RNA. These metabolites are known to be significant biomarkers
Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.
Yihan Wu et al.
Cell chemical biology, 24(12), 1437-1444 (2017-10-17)
Microbial natural products are genetically encoded by dedicated biosynthetic gene clusters (BGCs). A given BGC usually produces a family of related compounds that share a core but contain variable substituents. Though common, the reasons underlying this divergent biosynthesis are in
Michelle L Zaharik et al.
Microbiology (Reading, England), 153(Pt 8), 2472-2482 (2007-07-31)
Mutants capable of utilizing the pyrimidine biosynthetic intermediates carbamoylaspartate and dihydroorotate for growth were derived from pyrimidine auxotrophs of Salmonella enterica serovar Typhimurium LT2. The gain-of-function phenotypes both resulted from mutations in a single gene, yhiT, the third gene of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7128-500MG | 04061832397924 |
| D7128-5G | 04061832397931 |
| D7128-1G | 04061826016329 |