D7128
L-二氢乳清酸
≥99%
别名:
2,6-二氧六氢-4-嘧啶羧酸, L-氢乳清酸, 二氢-L-乳清酸
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关于此项目
经验公式（希尔记法）:
C5H6N2O4
化学文摘社编号:
分子量:
158.11
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Assay:
≥99%
Form:
powder
Application
L-二氢乳清酸(DHO)用作二氢乳清酸脱氢酶(DHODH)检测的底物。
Biochem/physiol Actions
L-二氢乳清酸(DHO)是二氢乳清酸脱氢酶(DHODH)的底物，而DHODH是一种从头合成嘧啶的酶。抑制剂对DHOH的抑制作用会导致上游代谢物DHO大量积累和尿苷水平下降。因此，DHO和尿苷可作为嘧啶合成的生物标志物，用于临床开发DHOH抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Feng Yin et al.
Journal of pharmaceutical and biomedical analysis, 192, 113669-113669 (2020-10-30)
Uridine and L-dihydroorotate (DHO) are important intermediates of de novo as well as salvage pathways for the biosynthesis of pyrimidines, which are the building blocks of nucleic acids - DNA and RNA. These metabolites are known to be significant biomarkers
Synergy and Target Promiscuity Drive Structural Divergence in Bacterial Alkylquinolone Biosynthesis.
Yihan Wu et al.
Cell chemical biology, 24(12), 1437-1444 (2017-10-17)
Microbial natural products are genetically encoded by dedicated biosynthetic gene clusters (BGCs). A given BGC usually produces a family of related compounds that share a core but contain variable substituents. Though common, the reasons underlying this divergent biosynthesis are in
Juliana Cheleski et al.
Analytical biochemistry, 399(1), 13-22 (2009-11-26)
Trypanosoma cruzi dihydroorotate dehydrogenase (TcDHODH) catalyzes the oxidation of l-dihydroorotate to orotate with concomitant reduction of fumarate to succinate in the de novo pyrimidine biosynthetic pathway. Based on the important need to characterize catalytic mechanism of TcDHODH, we have tailored
E Takashima et al.
Parasitology international, 50(4), 273-278 (2001-11-24)
Using N2 cavitation, we established a protocol to prepare the active mitochondria from Plasmodium falciparum showing a higher succinate dehydrogenase activity than previously reported and a dihydroorotate-dependent respiration. The fact that fumarate partially inhibited the dihydroorotate dependent respiration suggests that
Mark A Anderson et al.
Biochemistry, 45(23), 7132-7139 (2006-06-07)
In the pyrimidine biosynthetic pathway, N-carbamyl-L-aspartate (CA-asp) is converted to L-dihydroorotate (DHO) by dihydroorotase (DHOase). The mechanism of this important reaction was probed using primary and secondary 15N and 13C isotope effects on the ring opening of DHO using isotope
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