D7145
2′-脱氧鸟苷 一水合物
99-100%, synthetic (organic), powder
别名:
9-（2-脱氧-β-D-呋喃核糖基）鸟嘌呤, 鸟嘌呤-2′-脱氧核苷
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关于此项目
经验公式（希尔记法）:
C10H13N5O4 · H2O
化学文摘社编号:
分子量:
285.26
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
39814
Assay:
99-100%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear, colorless
产品名称
2′-脱氧鸟苷 一水合物, 99-100%
biological source
synthetic (organic)
Quality Level
assay
99-100%
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
SMILES string
O.NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](CO)O3)C(=O)N1
InChI
1S/C10H13N5O4.H2O/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6;/h3-6,16-17H,1-2H2,(H3,11,13,14,18);1H2/t4-,5+,6+;/m0./s1
InChI key
LZSCQUCOIRGCEJ-FPKZOZHISA-N
Application
2′-脱氧鸟苷一水合物作为核苷补充剂，可用于：
- 研究其对脱氧尿苷激酶(dguok)突变斑马鱼中线粒体DNA拷贝数的影响，
- 在组织培养基中用于合成脱氧核糖核苷酸(dNTP)，
- 在RPMI(Roswell Park Memorial Institute)-1640培养基中用于去除内源性胸腺细胞
Biochem/physiol Actions
脱氧鸟苷(dG)是一种嘌呤核苷，在激酶的连续磷酸化作用下可形成脱氧鸟苷三磷酸(dGTP)，dGTP可用于通过DNA聚合酶和逆转录酶合成DNA。在四种经典碱基中，脱氧鸟苷是最富电子的碱基，含有多个易受氧化损伤的亲核位点，因此脱氧鸟苷及其氧化衍生物可用于研究核苷和核苷酸的氧化损伤机制。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Takeji Takamura-Enya et al.
Bioorganic & medicinal chemistry letters, 21(14), 4206-4209 (2011-06-21)
BODIPY-modified 2'-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by a photo-induced electron transfer process. We attached BODIPY-Fl to the
Zimu Deng et al.
Methods in molecular biology (Clifton, N.J.), 1323, 151-158 (2015-08-22)
Reconstituted thymus organ culture is based on fetal thymus organ culture (FTOC). Purified thymocyte populations, from genetically modified mice or even from other species, are cultured in vitro with thymic lobes depleted of their endogenous thymocytes (by 2'-deoxyguanosine treatment) to
Aaron M Fleming et al.
Organic & biomolecular chemistry, 15(39), 8341-8353 (2017-09-25)
In DNA, 2'-deoxyguanosine (dG) is susceptible to oxidative modification by reactive oxygen species (ROS) yielding many products, one of which is 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG). Interestingly, dOG is stable but much more labile toward oxidation than dG, furnishing 5-guanidinohydantoin-2'-deoxyribose (dGh) that is
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7145-25MG | 04061833048016 |
| D7145-100MG | 04061833048009 |
| D7145-1G | 04061826738405 |
| D7145-5G | 04061833588239 |