D7321
香叶木素
别名:
3′,5,7-三羟基-4′-甲氧基黄酮, 4′-甲基木犀草素, 5,7-二羟基-2-（3-羟基-4-甲氧基苯基）色烯-4-酮, 木犀草素 4′-甲醚
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关于此项目
经验公式（希尔记法）:
C16H12O6
化学文摘社编号:
分子量:
300.26
UNSPSC Code:
12352205
NACRES:
NA.25
PubChem Substance ID:
EC Number:
208-291-8
Beilstein/REAXYS Number:
294492
MDL number:
InChI key
MBNGWHIJMBWFHU-UHFFFAOYSA-N
InChI
1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
SMILES string
COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
assay
≥98% (HPLC)
form
powder
color
light yellow to yellow
solubility
DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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General description
香叶木素是地奥司明的甲基化苷元黄酮。它大量存在于柑橘类水果， 油橄榄 L （橄榄树）的树叶，和豆科 金合欢 树中。
Application
香叶木素已被用于测试其对小鼠模型的慢性压力记忆和认知障碍的保护作用。
Biochem/physiol Actions
柑橘柠檬中的类黄酮。抗氧化剂。通过抑制CYP1A1酶抑制致癌物活化。
香叶木素表现出抗炎、抗癌、抗微生物、植物雌激素和保护神经的特性。它通过抑制核苷酸结合结构域(NOD)样受体蛋白3(NLRP3)炎性体和激活核因子红细胞2相关因子2(Nrf2)，显示出对脂多糖(LPS)诱导的急性肺损伤(ALI)的细胞保护作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Elham Saghaei et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 5725361-5725361 (2021-01-09)
In the present experimental study, male NMRI mice were exposed to chronic unpredictable mild stress (CUMS) paradigm for 35 days. Diosmetin (at doses of 10, 20, and 40 mg/kg. i.p.) or diosmetin solvent (normal saline + DMSO, 1 ml/kg; i.p.) was administered 30 min before
Qinmei Liu et al.
Biomolecules & therapeutics, 26(2), 157-166 (2017-04-04)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, an active component from Chinese herbs, has long been noticed because of its antioxidant
A review on pharmacological and analytical aspects of diosmetin: a concise report.
Patel, et al.
Chinese Journal of Integrative Medicine, 19, 792-800 (2018)
Miguel Angel Campanero et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 875-881 (2009-10-06)
Diosmetin (3',5,7-trihydroxy-4'-methoxyflavone) is the aglycone of the flavonoid glycoside diosmin (3',5,7-trihydroxy-4'-methoxyflavone-7-ramnoglucoside). Diosmin is hydrolyzed by enzymes of intestinal micro flora before absorption of its aglycone diosmetin. A specific, sensitive, precise, accurate and robust HPLC assay for the simultaneous determination of
Ya-Ling Hsu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 23(6), 949-960 (2008-02-14)
The survival of osteoblasts is one of the determinants of the development of osteoporosis. This study is the first to investigate the osteoblastic differentiation induced by diosmetin, a flavonoid derivative, in osteoblastic cell lines MG-63, hFOB, and MC3T3-E1 and bone
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