D7400
2′-脱氧腺苷 一水合物
≥99%, synthetic (organic), powder
别名:
9-（2-脱氧-β- D -呋喃核糖基）腺嘌呤, 腺嘌呤脱氧核苷
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关于此项目
经验公式（希尔记法）:
C10H13N5O3 · H2O
化学文摘社编号:
分子量:
269.26
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
213-488-7
MDL number:
Beilstein/REAXYS Number:
91015
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
Storage temp.:
2-8°C
产品名称
2′-脱氧腺苷 一水合物, ≥99%
biological source
synthetic (organic)
Quality Level
assay
≥99%
form
powder
solubility
water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
[H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
InChI
1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
InChI key
OLXZPDWKRNYJJZ-RRKCRQDMSA-N
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Application
2′-脱氧腺苷一水合物用于：
- 作为核苷补充品成分
- 作为标准品，估算增殖油棕胚性悬浮液中的DNA总甲基化率
- 逆转无菌α基序（SAM）和含组氨酸-天冬氨酸（HD）结构域的蛋白（SAMHD1）
- 抑制人类免疫缺陷病毒（HIV-1）和乙型肝炎病毒（HBV）
Biochem/physiol Actions
2′-脱氧腺苷（2′-dAdo），是脱氧核糖核苷，在能量应激的情况下可能被某些细胞用作能源，影响 cAMP的水平。 2′-dAdo 用于腺苷类似物在各种生物过程中功能的比较研究。
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
O Magnus et al.
International journal of fertility, 38(2), 123-128 (1993-03-01)
To find differences in effect on sperm motility of agents that increase intracellular cAMP: manganese ion, methyl-isobutyl-xanthine (MIX), 2-deoxyadenosine, glucose, and Mn-MIX and Mn-glucose. Nine men with asthenozoospermia vs. fertile donors. Sperm was washed in Hepes-buffered saline, motility tested by
Michela Giannecchini et al.
The international journal of biochemistry & cell biology, 37(4), 797-808 (2005-02-08)
In this paper, we report that cells undergoing metabolic stress conditions may use the ribose moiety of nucleosides as energy source to slow down cellular damage. In fact, the phosphorolytic cleavage of the N-glycosidic bond of nucleosides generates, without energy
Sonya M Schuh et al.
Biology of reproduction, 77(6), 960-969 (2007-09-01)
Activation of rapid motility apparently is one of the first steps of sperm capacitation and can be studied in vitro. Previously we found that 2-chloro-2'-deoxyadenosine or the catecholamine isoproterenol activates mouse sperm motility in vitro via a pathway mediated by
Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok-/- zebrafish
Munro B, et al.
Human Molecular Genetics, 28(5), 796-803 (2018)
Variations in genomic DNA methylation during the long-term in vitro proliferation of oil palm embryogenic suspension cultures
Rival A, et al.
Plant Cell Reports, 32(3), 359-368 (2013)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7400-250MG | 04061833048030 |
| D7400-500MG | 04061833588475 |
| D7400-1G | 04061826738429 |
| D7400-25G | 04061833588468 |
| D7400-5G | 04061833588482 |
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