D7409
2′,3′-双脱氧鸟苷 5′-三磷酸 钠盐
≥90% (HPLC)
别名:
ddGTP
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关于此项目
经验公式（希尔记法）:
C10H16N5O12P3
CAS Number:
分子量:
491.18
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
质量水平
方案
≥90% (HPLC)
表单
powder
溶解性
water: 5 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Na+].OP([O-])(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC(=N)Nc23
InChI
1S/C10H16N5O12P3.Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);/q;+1/p-1/t5-,6+;/m0./s1
InChI key
XCOBCPBPAINELA-RIHPBJNCSA-M
基因信息
human ... HRAS(3265)
相关类别
应用
2′,3′-二脱氧鸟苷 5′-三磷酸（ddGTP） 用作链终止剂抑制剂和端粒酶抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
H Jonckheere et al.
Journal of virological methods, 61(1-2), 113-125 (1996-09-01)
Many bacterial expression systems have been developed to study the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). This enzyme exists in the virions as a heterodimer of a 66 kDa (p66) subunit and a 51 kDa (p51)
Joeri Auwerx et al.
Molecular pharmacology, 65(1), 244-251 (2004-01-15)
To map the determinants of the lack of susceptibility of feline immunodeficiency virus (FIV) reverse transcriptase (RT) to anti human immunodeficiency virus type 1 (HIV-1) non-nucleoside RT inhibitors (NNRTIs), a variety of chimeric HIV-1/FIV RTs were constructed. The majority of
Tadamasa Sasaki et al.
The Plant journal : for cell and molecular biology, 47(5), 802-810 (2006-07-22)
RNA editing is found in various transcripts from land plant chloroplasts. In tobacco chloroplasts, C-to-U conversion occurs at 36 specific sites including two sites identified in this work. Our RNA editing assay system using chloroplast extracts facilitated biochemical analyses of
Z Debyser et al.
The Journal of biological chemistry, 267(17), 11769-11776 (1992-06-15)
Recently, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) compounds have been shown to be potent, selective, and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in vitro. They interact with the reverse transcriptase of HIV-1 in a way
H Zhang et al.
Antiviral research, 24(1), 43-57 (1994-05-01)
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially
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