D7441
Daltroban
>98% (HPLC)
别名:
4-[2-[(4-Chlorophenylsulfonyl)amino]ethyl]benzeneacetic acid, BM-13505, SKF-96148
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关于此项目
经验公式（希尔记法）:
C16H16ClNO4S
化学文摘社编号:
分子量:
353.82
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
>98% (HPLC)
表单
solid
颜色
white
mp
132.5-137.4 °C (lit.)
溶解性
DMSO: soluble 22 mg/mL
SMILES字符串
OC(=O)Cc1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1
InChI
1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
InChI key
IULOBWFWYDMECP-UHFFFAOYSA-N
基因信息
human ... TBXA2R(6915)
一般描述
Exerts protective effects on brain infarction, heart cell injury due to hypoxia and hypoglycemia and lowers serum CPK activity.
生化/生理作用
Selective thromboxane A2 receptor antagonist
特点和优势
This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
M Shimazawa et al.
European journal of pharmacology, 328(2-3), 183-189 (1997-06-11)
The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery. Pretreatment with
F Bertolino et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(4), 462-466 (1998-01-24)
We sought to determine whether the intrinsic pulmonary hypertensive activity of the purported thromboxane A2/prostanoid (TP) receptor antagonist, daltroban, was mediated by TP receptors, using the high efficacy TP receptor agonist, U-46619, and the silent TP receptor antagonist, SQ 29,548.
A Rizzo et al.
The American journal of physiology, 268(5 Pt 2), H1954-H1958 (1995-05-01)
The effects of platelet-activating factor (PAF) on vascular resistance and capillary permeability were studied in the isolated rat hindquarter. Six groups were studied (n = 30): control; PAF alone (1.4 microM); and PAF (1.4 microM) pretreated with ibuprofen (30 mg/kg)
Sabine Pestel et al.
Laboratory investigation; a journal of technical methods and pathology, 83(12), 1733-1741 (2003-12-24)
Various inflammatory stimuli such as anaphylatoxin C5a, zymosan, and lipopolysaccharides (LPSs) have been reported both to enhance glucose output in the perfused rat liver and to induce prostanoid (ie, prostaglandin and thromboxane) release from Kupffer cells, the resident liver macrophages.
Zhi-Dong Ge et al.
Journal of cardiovascular pharmacology, 41(3), 481-488 (2003-02-27)
The purpose of the current study was to compare the efficacy of two structurally unrelated thromboxane A (TXA ) receptor antagonists, KT2-962 and daltroban (BM 13.505), in a dog model of myocardial ischemia/reperfusion injury. Pentobarbital-anesthetized dogs were subjected to left
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