D7625
2′-脱氧胞苷 5′-单磷酸 钠盐
≥98%, microbial (fermentation), powder
别名:
dCMP, 胞嘧啶脱氧核苷酸
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关于此项目
线性分子式:
C9H12N3O7PNa2
化学文摘社编号:
分子量:
351.16
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
2′-脱氧胞苷 5′-单磷酸 钠盐, Sigma Grade, ≥98%
生物来源
microbial (fermentation)
等级
Sigma Grade
方案
≥98%
表单
powder
储存温度
−20°C
SMILES字符串
[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2
InChI
1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;
InChI key
BLEUYVBRJBDVEH-UHFFFAOYSA-N
应用
2′-脱氧胞苷-5′-单磷酸钠盐已被用于：
- 肾细胞癌（RCC）细胞SN12C的核苷稳定性研究
- 人肠道Caco-2细胞系和外周血单核细胞（PBMC）的细胞增殖研究
- 作为dsDNA激活诱导的胞苷脱氨酶结晶中的配体
将2′-脱氧胞苷-5-单磷酸（CMP）用作尿苷一磷酸（UMP）/胞苷一磷酸（CMP）激酶（EC 2.7.4.4）的底物以形成 dCDP，其在磷酸化至 dCTP 后，支持 DNA 和 RNA 生物合成。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)
Chih-Hung Hsu et al.
Molecular pharmacology, 67(3), 806-814 (2004-11-20)
Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs.
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
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