D7625
2′-脱氧胞苷 5′-单磷酸 钠盐
≥98%, microbial (fermentation), powder
别名:
dCMP, 胞嘧啶脱氧核苷酸
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关于此项目
线性分子式:
C9H12N3O7PNa2
化学文摘社编号:
分子量:
351.16
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
235-995-2
MDL number:
Assay:
≥98%
Biological source:
microbial (fermentation)
Form:
powder
Storage temp.:
−20°C
产品名称
2′-脱氧胞苷 5′-单磷酸 钠盐, Sigma Grade, ≥98%
InChI key
BLEUYVBRJBDVEH-UHFFFAOYSA-N
InChI
1S/C9H14N3O7P.Na.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17;;/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17);;
SMILES string
[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(O)=O)O2
biological source
microbial (fermentation)
grade
Sigma Grade
assay
≥98%
form
powder
storage temp.
−20°C
Quality Level
相关类别
Application
2′-脱氧胞苷-5′-单磷酸钠盐已被用于：
- 肾细胞癌（RCC）细胞SN12C的核苷稳定性研究
- 人肠道Caco-2细胞系和外周血单核细胞（PBMC）的细胞增殖研究
- 作为dsDNA激活诱导的胞苷脱氨酶结晶中的配体
将2′-脱氧胞苷-5-单磷酸（CMP）用作尿苷一磷酸（UMP）/胞苷一磷酸（CMP）激酶（EC 2.7.4.4）的底物以形成 dCDP，其在磷酸化至 dCTP 后，支持 DNA 和 RNA 生物合成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Zauri M, et al.
Nature, 524(7563), 114-114 (2015)
Rafael Andrade Caceres et al.
Journal of molecular modeling, 14(5), 427-434 (2008-03-18)
Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to, respectively, UDP and
AID recognizes structured DNA for class switch recombination
Qiao Q, et al.
Molecular Cell, 67(3), 361-373 (2017)
Dietary nucleotides and human immune cells. II. Modulation of PBMC growth and cytokine secretion
Holen E, et al.
Nutrition, 22(1), 90-96 (2006)
Dimitri Topalis et al.
The FEBS journal, 274(14), 3704-3714 (2007-07-05)
Methylanthraniloyl derivatives of ATP and CDP were used in vitro as fluorescent probes for the donor-binding and acceptor-binding sites of human UMP-CMP kinase, a nucleoside salvage pathway kinase. Like all NMP kinases, UMP-CMP kinase binds the phosphodonor, usually ATP, and
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