产品名称
磷酸二乙基伞形酮, ≥98% (HPLC), oil
SMILES string
CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1
InChI
1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
InChI key
GHGRYKAFUNNHBG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
oil
color
colorless to yellow
solubility
DMSO: >5 mg/mL
storage temp.
−20°C
Quality Level
Application
磷酸二乙酯已被用作脂肪酶抑制剂来治疗野生型成髓细胞，以进行体外中性粒细胞分化试验。
Biochem/physiol Actions
二乙基伞形磷酸酯（DEUP）是一种在体外不阻断蛋白激酶活性A的有机磷酸酯。
二乙基伞形酮磷酸酯是一种选择性的、有效的胆固醇酯酶抑制剂。它主要通过防止胆固醇转运到类固醇生成细胞的线粒体中来阻止类固醇生成。预期胆固醇酯酶抑制剂会限制饮食中胆固醇的吸收。IC50 = 11.6 μM。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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商品
Cholesterol esterification enhances transport efficiency in lipoproteins for increased blood stream transport.
胆固醇酯化可改善运输。胆固醇酯可更轻松地封装在脂蛋白内部-增加了在血液中可轻松运输的胆固醇数量。
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