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D7693

Dynasore 水合物

Name: Dynasore 水合物
Brand: SIGMA

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

别名:

3-羟基-萘-2-羧酸（3,4-二羟基-亚苄基）-酰肼水合物

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关于此项目

经验公式（希尔记法）:

C₁₈H₁₄N₂O₄ · xH₂O

化学文摘社编号:

1202867-00-2

分子量:

322.31 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329798784

NACRES:

NA.77

MDL number:

MFCD11045288

Form:

powder

Quality level:

100

Storage condition:

protect from light

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产品名称

Dynasore 水合物,

form

powder

Quality Level

100

storage condition

protect from light

color

off-white

solubility

DMSO: ≥10 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

InChI key

FKWZHQSDBMSHTN-ZIOFAICLSA-N

General description

Dynasore是一种小分子GTP酶抑制剂，其可靶向发动蛋白-1、发动蛋白-2和Drp1（线粒体）。Dynasore可阻断发动蛋白依赖的内吞作用，以及内吞囊泡的断裂。Dynosore是促纤维化的，可在胸膜间皮细胞中诱导PAI-1，且可能成为有效的胸膜固定剂。Dynasor可阻断人乳头瘤病毒16型（HPV16）和牛乳头瘤病毒1型（BPV1）（假病毒粒子）的感染。
Dynasore水合物可降低质膜中的不稳定胆固醇水平并破坏脂筏组织。Dynasore对单纯疱疹病毒（HSV）-1和HSV-2感染具有多效性。它阻碍了病毒进入、病毒蛋白的运输和衣壳的形成。

Application

Dynasore水合物已被用于：

引发胎儿间充质干/基质细胞（fMSC）
共聚焦显微镜检测
伤口愈合/划痕和管形成测定
分析其对柯萨奇病毒A9（CAV9）感染的影响
抑制网格蛋白介导的内吞作用和小窝蛋白介导的内吞作用
细胞的实时成像

Biochem/physiol Actions

Dynasore是一种细胞渗透性、可逆的非竞争性发动蛋白1和发动蛋白2的GTP酶活性抑制剂。

Features and Benefits

该化合物是环核苷酸研究的推荐产品。点击此处，了解更多精选环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

pictograms

GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000537931

0000513409

0000454894

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Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells

Pelekanos RA, et al.

BMC Cell Biology, 15(1), 15-15 (2014)

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT).

Florian Ehlgen et al.

PloS one, 7(6), e38781-e38781 (2012-06-22)

Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane

Dynasore-not just a dynamin inhibitor

Preta G, et al.

Cell communication and signaling : CCS, 13(1), 24-24 (2015)

Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study.

Richard H Tuligenga et al.

The lancet. Diabetes & endocrinology, 2(3), 228-235 (2014-03-14)

Type 2 diabetes increases the risk for dementia, but whether it affects cognition before old age is unclear. We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline. 5653 participants from

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

Tom Kirchhausen et al.

Methods in enzymology, 438, 77-93 (2008-04-17)

The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for

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全球贸易项目编号

货号	GTIN
D7693-25MG	04061832981444
D7693-5MG	04061833588765

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