D7750
2′-脱氧胞苷 5′-单磷酸
≥95.0%, synthetic, powder
别名:
dCMP, 胞嘧啶脱氧核苷酸
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关于此项目
经验公式（希尔记法）:
C9H14N3O7P
化学文摘社编号:
分子量:
307.20
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
213-849-9
MDL number:
Beilstein/REAXYS Number:
41062
Assay:
≥95.0%
Biological source:
synthetic
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
产品名称
2′-脱氧胞苷 5′-单磷酸, Sigma Grade, ≥95.0%
biological source
synthetic
Quality Level
grade
Sigma Grade
assay
≥95.0%
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2
InChI
1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
InChI key
NCMVOABPESMRCP-SHYZEUOFSA-N
相关类别
General description
2′-脱氧胞苷 5′-单磷酸酯是构成DNA的脱氧核苷酸的结构单元。它由通过N-β-D-糖苷键连接含氮杂环胞嘧啶而形成的2′-脱氧-β-D-呋喃核糖组成。它在C-5 处被磷酸化′。
Application
2′-脱氧胞苷5′-单磷酸酯已被用于拉曼光谱研究，以确定其拉曼总半带宽。
2'-脱氧胞苷5'-单磷酸（dCMP）利用尿苷单磷酸（UMP）/单磷酸胞苷（CMP）激酶（EC 2.7.4.4）的底物，形成dCDP，其在磷酸化为dCTP时支持DNA生物合成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ivan Zlatev et al.
Bioorganic & medicinal chemistry, 17(19), 7008-7014 (2009-09-01)
The replacement of the pyrophosphate moiety of 2'-deoxynucleoside triphosphates by non natural delta-dicarboxylic butyl amino acid allows incorporation of natural 2'-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3'-deoxycytidine analogue was not a substrate of
Susan Quinn et al.
Chemical communications (Cambridge, England), (21)(21), 2130-2132 (2007-05-24)
A strong infrared band at 1574 cm(-1) is observed following 267 nm excitation of 2'-deoxycytidine (tau = 37 +/- 4 ps) or 2'-deoxycytidine 5'-monophosphate (tau = 33 +/- 4 ps); this band is provisionally attributed to an 1n(N)pi* state and
Makusu Tsutsui et al.
Journal of the American Chemical Society, 133(23), 9124-9128 (2011-05-13)
We report label-free electrical detections of chemically modified nucleobases in a DNA using a nucleotide-sized electrode gap. We found that methyl substitution contributes to increase the tunneling conductance of deoxycytidines, which was attributed to a shift of the highest occupied
Zimin Liu et al.
American journal of translational research, 8(11), 4764-4777 (2016-12-03)
microRNAs (miRs) are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence suggests that microRNA-221 (miR-221) plays important roles in human carcinogenesis. It
Dimitri Topalis et al.
Journal of medicinal chemistry, 54(1), 222-232 (2010-12-07)
Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps catalyzed by cellular kinases. New pyrimidine ANPs have been synthesized with unsaturated acyclic side
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7750-1G | 04061826690611 |
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