D7810
Anti-Daxx antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-BING2, Anti-DAP6, Anti-EAP1, Anti-SMIM40
产品名称
Anti-Daxx antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 120 kDa
species reactivity
mouse, human, monkey
technique(s)
microarray: suitable
western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DAXX(1616)
mouse ... Daxx(13163)
Application
Anti-Daxx antibody is suitable for:
- western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
- microarray
- the detection and localization of Daxx by immunoblotting
Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.
Biochem/physiol Actions
Anti-Daxx specifically recognizes human Daxx (120 kDa).
The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).
Immunogen
Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
The replication defect of ICP0-null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71
Everett RD, et al.
Journal of virology, 87(2), 978-990 (2013)
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis
Zhong S, et al.
The Journal of Experimental Medicine, 191(4), 631-640 (2000)
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity
Ecsedy JA, et al.
Molecular and Cellular Biology, 23(3), 950-960 (2003)
Philipp E Merkl et al.
Journal of virology, 92(10) (2018-03-02)
The initial events after DNA virus infection involve a race between epigenetic silencing of the incoming viral DNA by host cell factors and expression of viral genes. Several host gene products, including the nuclear domain 10 (ND10) components PML (promyelocytic
The ?readers? of unacetylated p53 represent a new class of acidic domain proteins
Wang D, et al.
Nucleus (Austin, Tex.), 8(4), 360-369 (2017)
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