D7909
Dicyclomine hydrochloride
≥99% (TLC), powder
别名:
2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride, [1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H35NO2 · HCl
化学文摘社编号:
分子量:
345.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-671-1
MDL number:
InChI key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
InChI
1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
SMILES string
CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]
assay
≥99% (TLC)
form
powder
color
off-white
solubility
H2O: 50 mg/mL
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Biochem/physiol Actions
Competitive muscarinic acetylcholine receptor antagonist.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Nav Persaud et al.
The International journal of risk & safety in medicine, 24(1), 31-35 (2012-03-23)
Until recently epidemiological evidence was not regarded as helpful in determining cause and effect. It generated associations that then had to be explained in terms of bio-mechanisms and applied to individual patients. A series of legal cases surrounding possible birth
Christopher D Cox et al.
Journal of neurotrauma, 25(11), 1355-1365 (2008-12-09)
Recent studies indicate that alphaII-spectrin breakdown products (SBDPs) have utility as biological markers of traumatic brain injury (TBI). However, the utility of SBDP biomarkers for detecting effects of therapeutic interventions has not been explored. Acetylcholine plays a role in pathological
Surabi Veeraragavan et al.
Psychopharmacology, 217(1), 143-151 (2011-04-14)
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors, widely expressed in the CNS. Electrophysiological and molecular studies have provided evidence for overactive M1 receptor signaling in the fragile X knockout (Fmr1 KO) mouse model, suggesting the involvement of the M1
Larissa Zeggio Perez Figueredo et al.
Brain research bulletin, 77(2-3), 71-76 (2008-06-28)
A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction
P Grillner et al.
Neuroscience, 91(2), 557-565 (1999-06-12)
The effects of carbachol (0.01-30 microM) and muscarine (10-30 microM) on the excitatory synaptic potentials were studied using conventional intracellular recordings from dopaminergic neurons in rat mesencephalic slices. Both muscarinic agonists reversibly reduced the excitatory synaptic potentials, evoked by local
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