D7909
Dicyclomine hydrochloride
≥99% (TLC), powder
别名:
2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride, [1,1-Bicyclohexyl]-1-carboxylic acid 2-(diethylamino)ethyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H35NO2 · HCl
化学文摘社编号:
分子量:
345.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-671-1
MDL number:
InChI key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
InChI
1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
SMILES string
CCN(CCOC(C1(C2CCCCC2)CCCCC1)=O)CC.[Cl]
assay
≥99% (TLC)
form
powder
color
off-white
solubility
H2O: 50 mg/mL
Quality Level
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Biochem/physiol Actions
Competitive muscarinic acetylcholine receptor antagonist.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Arthur Staroselsky et al.
Gastroenterology, 132(2), 824-825 (2007-01-31)
Andrea M Robinson et al.
Journal of psychopharmacology (Oxford, England), 26(8), 1143-1150 (2011-09-06)
The cholinergic system is known to be necessary for normal attentional processing. However, the receptors and mechanisms mediating the effects of acetylcholine on attention remain unclear. Previous work in our laboratory suggested that cholinergic muscarinic receptors are critical for maintaining
Larissa Zeggio Perez Figueredo et al.
Brain research bulletin, 77(2-3), 71-76 (2008-06-28)
A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction
Z W Jiang et al.
Brain research, 852(1), 37-44 (2000-02-08)
The rat subdural hematoma (SDH) model produces a zone of ischemic brain damage within the hemisphere beneath the SDH. Previous studies have measured large increases in extracellular acetylcholine during cerebral ischemia in the rat. We examined infarct volume after selectively
Surabi Veeraragavan et al.
Psychopharmacology, 217(1), 143-151 (2011-04-14)
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors, widely expressed in the CNS. Electrophysiological and molecular studies have provided evidence for overactive M1 receptor signaling in the fragile X knockout (Fmr1 KO) mouse model, suggesting the involvement of the M1
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