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Merck
CN

D7910

Sigma-Aldrich

3,4-二氯异香豆素

≥98% (TLC), Serine protease inhibitor, powder

别名:

3,4-DCI, 3,4-二氯-2-苯并吡喃-1-酮

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关于此项目

经验公式（希尔记法）:
C9H4Cl2O2
CAS Number:
51050-59-0
分子量:
215.03
Beilstein:
6802625
MDL编号:
MFCD00036960
UNSPSC代码:
12352202
PubChem化学物质编号:
24278386
NACRES:
NA.77

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Product Name

3,4-二氯异香豆素, serine protease inhibitor

质量水平

200

方案

≥98% (TLC)

表单

powder

溶解性

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

储存温度

2-8°C

SMILES字符串

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

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相关类别

一般描述

丝氨酸蛋白酶抑制剂。对包括颗粒酶内部的多种丝氨酸蛋白酶具有活性。对β-内酰胺酶无活性。

应用

可用于巨噬细胞的快速染色鉴定；通过更复杂的形态学标准、吞噬作用和 Fc 受体的存在证实了该方法的计数。

制备说明

PH 7.5 时半衰期 = 20 分钟。

其他说明

有效浓度为 5-100μM。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000420474
0000301459
0000301459
0000420474
0000249570

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Anežka Tichá et al.
Cell chemical biology, 24(12), 1523-1536 (2017-11-07)
Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped. Here, we
A Weihofen et al.
The Journal of biological chemistry, 275(40), 30951-30956 (2000-08-02)
Signal peptides of secretory and membrane proteins are generated by proteolytic processing of precursor proteins after insertion into the endoplasmic reticulum membrane. Liberated signal peptides can be further processed, and the resulting N-terminal fragments are released toward the cytosol, where
V Conseil et al.
Antimicrobial agents and chemotherapy, 43(6), 1358-1361 (1999-05-29)
We investigated the effect of protease inhibitors on the asexual development of the protozoan parasite Toxoplasma gondii. Among the inhibitors tested only two irreversible serine protease inhibitors, 3,4-dichloroisocoumarin and 4-(2-aminoethyl)-benzenesulfonyl fluoride, clearly prevented invasion of the host cells by specifically
Diego López León et al.
iScience, 23(3), 100932-100932 (2020-03-11)
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show
Premkumari Kumarathasan et al.
Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)
There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a
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