D8065
Dephostatin
>98% (HPLC), solid
别名:
1,4-Dihydroxy-N-methyl-N-nitrosoaniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)hydroquinone
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关于此项目
经验公式（希尔记法）:
C7H8N2O3
化学文摘社编号:
分子量:
168.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CN(N=O)c1cc(O)ccc1O
assay
>98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: soluble 22 mg/mL, H2O: insoluble
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PTPRCAP(5790)
Biochem/physiol Actions
CD45-associated protein tyrosine phosphatase inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Laurent Gaté et al.
Biochemical pharmacology, 65(10), 1611-1622 (2003-05-20)
Glutathione S-transferase pi (GSTpi; EC 2.5.1.18) has been shown recently to be a regulator of mitogen-activated protein kinases (MAPK). We have developed, by chronic exposure of HL60 cells to increasing concentrations of a peptidomimetic GSTpi inhibitor TLK199, a 10-fold resistant
Waleed El-Beialy et al.
The Journal of membrane biology, 233(1-3), 119-126 (2010-02-05)
Modulation of the physiologically influential Na(+),K(+)-ATPase is a complex process involving a wide variety of factors. To determine the possible effects of the protein tyrosine phosphatase (PTP) inhibitors dephostatin and Et-3,4-dephostatin on human and pig, renal cells and enzymatic extracts
M Mackova et al.
Endocrinology, 141(11), 4202-4208 (2000-11-23)
Interaction between p38MAPK and p42/44MAPK in rat pinealocytes was examined by determining the effects of p38MAPK inhibitors on the phosphorylation of p42/44MAPK using Western blot analysis. Treatment with SB202190, a specific inhibitor of p38MAPK, increased p42/44MAPK phosphorylation in a concentration-dependent
S Wijetunge et al.
British journal of pharmacology, 124(2), 307-316 (1998-06-26)
1. The effect of increasing cellular tyrosine phosphorylation by inhibiting endogenous tyrosine phosphatases was examined on voltage-operated calcium channel currents in vascular smooth muscle cells. 2. In single ear artery smooth muscle cells of the rabbit, studied by the whole
Anna Asplund Persson et al.
European journal of pharmacology, 521(1-3), 124-132 (2005-09-27)
We examined the effects of the nitrosoamine dephostatin on the nitric oxide (NO)/cyclic guanosine 3',5'-monophosphate (cGMP)-signalling in porcine iliac arteries. Dephostatin has been characterised as a tyrosine phosphatase inhibitor, but Western blot analyses showed that dephostatin did not augment tyrosine
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