D8174
9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α
≥98% (HPLC), solution, thromboxane A2 agonist
别名:
U-46619, U46619
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关于此项目
经验公式（希尔记法）:
C21H34O4
CAS Number:
分子量:
350.49
Beilstein:
4267334
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
Product Name
9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α, solution, 10 mg/mL in methyl acetate
表单
solution
质量水平
浓度
10 mg/mL in methyl acetate
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
InChI
1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
InChI key
LQANGKSBLPMBTJ-REGKDVDGSA-N
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相关类别
一般描述
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种内过氧化物/血栓素类似物。
应用
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α已用于：
- 诱导肌球蛋白轻链9（Myl9）基因缺失的小鼠的主动脉平滑肌（SM）收缩
- 诱导收缩作为小鼠主动脉血管反应性实验的一部分
- 作为血栓素/前列腺激动剂，以研究二硫苏糖醇（DTT）对小鼠动脉血管活性的影响
生化/生理作用
9,11-双脱氧-11α,9α-环氧基甲烷前列腺素F2α是一种血栓素A2激动剂。它可在体外实验中诱导血小板的形状变化、凝集、分泌、磷酸肌醇水解和蛋白质磷酸化。它还会引起胞质Ca++水平的升高，轻微影响环磷酸腺苷（cAMP）的形成。它可用作血管细胞粘附分子-1（VCAM-1）的有效刺激因子，以介导白细胞粘附至内皮细胞。
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官
Central nervous system
补充剂危害
储存分类代码
3 - Flammable liquids
WGK
WGK 2
闪点(°F)
14.0 °F
闪点(°C)
-10 °C
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D Nakladal et al.
Scientific reports, 9(1), 13-13 (2019-01-11)
SUL-compounds are protectants from cold-induced ischemia and mitochondrial dysfunction. We discovered that adding SUL-121 to renal grafts during warm machine reperfusion elicits a rapid improvement in perfusion parameters. Therefore, we investigate the molecular mechanisms of action in porcine intrarenal arteries
Marta Brambilla et al.
Platelets, 29(4), 406-414 (2017-06-24)
Tissue factor (TF), the key activator of the blood coagulation cascade and of thrombus formation, is also expressed by circulating human platelets. Despite the documented in-depth characterization of platelet TF carried out in the past 15 years, some authors still
Jean Bismuth et al.
Medical science monitor : international medical journal of experimental and clinical research, 15(9), BR270-BR274 (2009-09-02)
Lactosylceramide (LacCer) is a member of the glycosphingolipid family, which has been implicated in the atherogenic process. The goal of this study was to determine the effects and molecular mechanisms of LacCer on endothelial functions in porcine coronary arteries and
Yu-Xiang Fei et al.
Journal of ethnopharmacology, 207, 57-66 (2017-06-25)
Danshen is a crude herbal drug isolated from dried roots of Salvia miltiorrhiza Bunge. This plant is widely used in oriental medicine for the treatment of cardiovascular and cerebrovascular diseases. The supercritical CO The present study was designed to observe
Jonas Tind Hansen et al.
PloS one, 8(3), e58890-e58890 (2013-03-22)
Functional cross-talk between seven transmembrane (7TM) receptors can dramatically alter their pharmacological properties, both in vitro and in vivo. This represents an opportunity for the development of novel therapeutics that potentially target more specific biological effects while causing fewer adverse
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