D8281
Anti-Desmin antibody produced in rabbit
whole antiserum
别名:
Anti-Desmin, Desmin Detection Antibody, Rabbit Anti-Desmin
产品名称
Anti-Desmin antibody produced in rabbit, whole antiserum
biological source
rabbit
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
contains
15 mM sodium azide
species reactivity
chicken, bovine, human, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
indirect immunofluorescence: 1:20 using cultured cells
indirect immunofluorescence: 1:20 using human skeletal muscle sections
western blot: 1:100 using animal or human skeletal muscle.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DES(1674)
mouse ... Des(13346)
Application
Anti-Desmin antibody produced in rabbit has been used in:
- immunohistochemistry of zebrafish intestines sections
- immunodetection in fish embryo samples
- immunolabeling of myofibers
Anti-desmin antibody can be used in immunocytochemistry and western immunoblotting. It can also be used in indirect immunofluorescence.
Biochem/physiol Actions
Desmin plays a crucial role in providing mechanical strength to muscle tissues. Mutations in desmin gene contributes to imbalance in skeletal proteins, resulting in desminopathies. Missense mutations in desmin gene leads to hypertrophic cardiomyopathy and systemic myopathy. Mutations in desmin gene impairs the stability of intermediary filaments in cardiomyocytes, contributing to pathophysiology of cardiac diseases.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Desmin is an intermediate filament protein found mainly in skeletal, cardiac, and smooth muscle cells. It acts as a marker for tumor origin. It also facilitates mechanical support for muscles, mitochondrial localization, myofibrillogenesis, gene expression regulation, and intracellular signalling. Anti-desmin antibody can be used for immunocytochemical localization of intermediate filaments in all types of muscle cells. It can also be used to stain a wide desmin band of 50,000 to 55,000 molecular weight using immunoblotting assays. Rabbit anti-desmin antibody reacts specifically with desmin in bovine, mouse, chicken and human.
Desmin is mapped to human chromosome 2q35. The desmin protein comprises of a head domain, four α-helical segments, three non-helical rod segments and a tail domain. It exists as dimer and tetramer assemblies. In smooth and striated muscles, desmin is localized in the periphery of Z-disk.
Immunogen
desmin from chicken gizzard
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
此项目有
Epigenetic factors coordinate intestinal development.
Ganz J, et al.
bioRxiv, 7(14), 399410-399410 (2018)
Functional characterization of the novel DES mutation p. L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.
Brodehl A, et al.
Journal of Molecular and Cellular Cardiology, 91(1), 207-214 (2016)
Myogenin promotes myocyte fusion to balance fibre number and size.
Ganassi M, et al.
Nature Communications, 9(1), 4232-4232 (2018)
Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity.
Alam S, et al.
Journal of the American Heart Association, 7(14), e009289-e009289 (2018)
Imbalances in protein homeostasis caused by mutant desmin.
Winter L, et al.
Neuropathology and Applied Neurobiology (2018)
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