D8783
7-脱氮-2′-脱氧鸟苷5′-三磷酸 锂盐
10 mM in H2O
别名:
−N7-dGTP, 7-脱氮-dGTP
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关于此项目
经验公式（希尔记法）:
C11H17N4O13P3
化学文摘社编号:
分子量:
506.19
NACRES:
NA.52
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥95% (HPLC)
Biological source:
Porcine muscle
rabbit muscle
rabbit muscle
Form:
liquid
Storage temp.:
−20°C
产品名称
7-脱氮-2′-脱氧鸟苷5′-三磷酸 锂盐, 10 mM in H2O
InChI
1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)
SMILES string
NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1
InChI key
DLLXAZJTLIUPAI-UHFFFAOYSA-N
biological source
Porcine muscle
rabbit muscle
assay
≥95% (HPLC)
form
liquid
concentration
10 mM in H2O
color
colorless
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Application
7-脱氮-2′-脱氧鸟苷-5′-三磷酸锂盐已用作裂解剂，评估其直接细胞裂解的效率、RNA稳定性，以及在分析少量细胞样品时与下游逆转录定量实时PCR的兼容性。
Biochem/physiol Actions
7-脱氮-2′-脱氧鸟苷-5′-三磷酸 (7-deaza-dGTP) 与天然底物 dGTP 竞争并阻断端粒酶活性。该核苷酸掺入端粒后，会即刻改变端粒的二级结构，使端粒酶难以识别它，无法进一步合成端粒。这种dGTP类似物可与常规碱基弱配对，最大限度地减少DNA二级结构的形成，同时成为DNA聚合酶的良好底物。7-deaza-dGTP与二甲基亚砜 (DMSO) 和甜菜碱结合使用可增强富含GC的 DNA 序列的聚合酶链式反应 (PCR) 扩增。
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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