D8946
DMH1
≥98% (HPLC), powder, BMP inhibitor
别名:
4- [6- [4-（1-甲基乙氧基）苯基] 吡唑并 [1,5-a] 嘧啶-3-基]-喹啉, 4-[6-（4-异丙氧基苯基）吡唑并 [1,5-a] 嘧啶-3-基] 喹啉
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关于此项目
经验公式（希尔记法）:
C24H20N4O
化学文摘社编号:
分子量:
380.44
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
DMH1, ≥98% (HPLC)
Quality Level
SMILES string
CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3
InChI key
JMIFGARJSWXZSH-UHFFFAOYSA-N
InChI
1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to orange
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
相关类别
Application
DMH1 已被用于骨形态发生蛋白 (BMP) 抑制。 也被用于阻断血管内皮生长因子 (VEGF) 信号。
Biochem/physiol Actions
DMH1 是一种高选择性骨形态发生蛋白 (BMP) 抑制剂。
DMH1 是一种高选择性骨形态发生蛋白 (BMP) 抑制剂。DMH1 是一种 Dorsomorphin 类似物，仅靶向 BMP ，但不是 VEGF 通路。
General description
DMH1 刺激人类诱导多能干细胞 (hiPSCs) 的神经发生并抑制肺癌的生长和转移。它阻止细胞自噬反应。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Silvia Colucci et al.
Blood, 130(19), 2111-2120 (2017-09-03)
The expression of the key regulator of iron homeostasis hepcidin is activated by the BMP-SMAD pathway in response to iron and inflammation and among drugs, by rapamycin, which inhibits mTOR in complex with the immunophilin FKBP12. FKBP12 interacts with BMP
An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta
Lanza AR, et al.
Developmental Biology, 435(1), 26-40 (2018)
DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy
Sheng Y, et al.
Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)
BMP signaling is required for nkx2. 3-positive pharyngeal pouch progenitor specification in zebrafish
Li Linwei, et al.
PLoS Genetics, 15(2), e1007996-e1007996 (2019)
Mylah Villacorte et al.
Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)
Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized
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