D9035
二氮嗪
≥98% (TLC), powder, ATP-sensitive K⁺ channel activator
别名:
7-氯-3-甲基-2H-1,2,4-苯并噻二嗪 1,1-二氧化物
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关于此项目
经验公式（希尔记法）:
C8H7ClN2O2S
化学文摘社编号:
分子量:
230.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352119
EC Number:
206-668-1
MDL number:
产品名称
二氮嗪,
InChI key
GDLBFKVLRPITMI-UHFFFAOYSA-N
InChI
1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
SMILES string
CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
form
powder
solubility
0.1 M NaOH: soluble
H2O: insoluble
methanol: soluble
originator
Schering Plough
Quality Level
Gene Information
human ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778)
mouse ... Kcnj1(56379), Kcnj11(16514)
rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)
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相关类别
Application
二氮嗪已用于二氮嗪输注。 也用于防止 K + 诱导的胞吐作用的去极化。
Biochem/physiol Actions
血管平滑肌和胰岛 β 细胞中的选择性 ATP 敏感性 K + 通道激活剂-细胞；抗高血压药。
Features and Benefits
该化合物由Schering Plough开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
General description
二氮嗪是一种非利尿性苯并噻二嗪类药物，用于治疗低血糖、血管性血友病、急性和恶性高血压。作为 β 细胞 KATP 通道开放剂，二氮嗪可防止胰岛素的分泌。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Stability of diazoxide in extemporaneously compounded oral suspensions
Friciu M, et al.
Testing, 11(10), e0164577-e0164577 (2016)
Diazoxide Attenuates Ischemic Myocardial Injury in a Porcine Model
Sarja H, et al.
The Heart Surgery Forum (2017)
T Grimmsmann et al.
British journal of pharmacology, 123(5), 781-788 (1998-04-16)
1. The direct effects of diazoxide on mitochondrial membrane potential, Ca2+ transport, oxygen consumption and ATP generation were investigated in mouse pancreatic B-cells and rat liver mitochondria. 2. Diazoxide, at concentrations commonly used to open adenosine 5'-triphosphate (ATP)-dependent K+-channels (K(ATP)
Pharmacological Preconditioning with Diazoxide in the Experimental Hypothermic Circulatory Arrest Model
Haapanen H, et al.
The Heart Surgery Forum (2017)
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.
Fink MK and Klement RJ
Oncologist, 22(4), 491-491 (2017)
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