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Merck
CN

D9069

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

别名:

(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548

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关于此项目

经验公式（希尔记法）:
C25H27NO·HCl
化学文摘社编号:
15917-65-4
分子量:
393.95
NACRES:
NA.77
PubChem Substance ID:
329798889
UNSPSC Code:
12352203
MDL number:
MFCD03423594

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InChI

1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

SMILES string

Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3

InChI key

GMLHJWZEYLTNJW-BJFQDICYSA-N

sterility

non-sterile

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

technique(s)

inhibition assay: suitable

solubility

DMSO: ≥20 mg/mL

shipped in

ambient

storage temp.

room temp

Quality Level

100

相关类别

Application

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000344629
0000344629
0000258810
0000255684
0000255684

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Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
Hackett AR, et al.
Experimental Neurobiology, 308, 72-79 (2018)
Altin Sula et al.
Molecular cell, 81(6), 1160-1169 (2021-01-28)
Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well characterized. We describe the identification of a previously unidentified receptor site within the NavMs voltage-gated sodium channel. Tamoxifen, an estrogen

商品

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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