D9160
1-甘露糖野尻霉素 盐酸盐
别名:
1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride
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关于此项目
经验公式（希尔记法）:
C6H13NO4 · HCl
化学文摘社编号:
分子量:
199.63
NACRES:
NA.76
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
InChI key
ZJIHMALTJRDNQI-MVNLRXSJSA-N
SMILES string
Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
form
powder
color
white to off-white
solubility
H2O: 10 mg/mL
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
2-8°C
Quality Level
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Application
1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.
Biochem/physiol Actions
1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.
Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.
General description
Chemical structure: glucosamine
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
E U Bagriaçik et al.
Glycobiology, 6(4), 413-421 (1996-06-01)
The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence supporting a role for N-linked carbohydrate stems from the treatment
Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells.
Janike Ehret et al.
Biotechnology and bioengineering, 116(4), 816-830 (2018-12-16)
Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of
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