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Merck
CN

D9190

DCEBIO

≥98% (HPLC), solid

别名:

5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one

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关于此项目

经验公式(希尔记法):
C9H8N2OCl2
化学文摘社编号:
分子量:
231.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >10 mg/mL

SMILES string

CCN1C(=O)Nc2cc(Cl)c(Cl)cc12

InChI

1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)

InChI key

LKHRMULASXZCLG-UHFFFAOYSA-N

Biochem/physiol Actions

DCEBIO facilitates Cl secretion in the epithelia by activating K+ and Cl currents.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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David F Stowe et al.
Journal of cardiovascular pharmacology, 70(5), 314-328 (2017-08-05)
Both big (BKCa) and small (SKCa) conductance Ca-sensitive K channels are present in mammalian cardiac cell mitochondria (m). We used pharmacological agonists and antagonists of BKCa and SKCa channels to examine the importance of endogenous opening of these channels and
Naoto Fujii et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(2), R390-R398 (2020-01-09)
Local skin heating to 42°C causes cutaneous thermal hyperemia largely via nitric oxide (NO) synthase (NOS)-related mechanisms. We assessed the hypothesis that ATP-sensitive K+ (KATP) channels interact with NOS to mediate cutaneous thermal hyperemia. In 13 young adults (6 women
Jelena Sikimic et al.
Frontiers in endocrinology, 11, 545638-545638 (2020-11-17)
Congenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants. Poor efficacy and strong adverse effects of the current medications impede successful treatment.
Amy N Savitski et al.
Respiratory research, 10, 120-120 (2009-12-01)
Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subsequent mucus retention contributes to the pathophysiology of each of these diseases, suggesting that
Pei-Chun Chen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(6), 2374-2388 (2018-08-17)
Intermediate-conductance Ca2+-activated K+ (IKCa; KCa3.1 or KCNN4) channels affect the behaviors of central neurons including motor neurons. The mechanism through which neuronal differentiation is related to the activity of these channels remains largely unclear. By using various molecular biology tools

全球贸易项目编号

货号GTIN
D9190-25MG04061832574394
D9190-5MG04061832574400

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