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Merck
CN

D9315

溴氰菊酯

≥98%

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关于此项目

经验公式(希尔记法):
C22H19Br2NO3
化学文摘社编号:
分子量:
505.20
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
258-256-6
Beilstein/REAXYS Number:
6746312
MDL number:
Assay:
≥98%
Form:
solid
Quality level:
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Quality Level

assay

≥98%

form

solid

storage temp.

−20°C

SMILES string

CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2

InChI

1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1

InChI key

OWZREIFADZCYQD-NSHGMRRFSA-N

Application

溴氰菊酯已被用于:
  • 通过处理HEK293(人类胚胎肾细胞)Tau-BiFC细胞,研究其作为PP2A/PPP3CA抑制剂的影响
  • 研究其对虹鳟鱼的天生免疫力的影响
  • 研究其对虎虾斑节对虾分子应激水平的影响

Biochem/physiol Actions

溴氰菊酯是一种 Ⅱ 类型半合成除虫菊酯,其作为钙调磷酸酶(蛋白磷酸酶 2B)的强效抑制剂,IC 50 约为 100 pM。这种抑制作用通过引起非突变钙通道长时间保持开放,允许大量 Ca2+ 进入细胞内,从而导致细胞过度兴奋。一些钠通道突变显示如非洲爪蟾卵母细胞的 L993F 突变,显示出对溴氰菊酯的敏感性降低。


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pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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