D9315
溴氰菊酯
≥98%
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关于此项目
经验公式（希尔记法）:
C22H19Br2NO3
化学文摘社编号:
分子量:
505.20
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
258-256-6
Beilstein/REAXYS Number:
6746312
MDL number:
InChI
1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1
InChI key
OWZREIFADZCYQD-NSHGMRRFSA-N
SMILES string
CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2
assay
≥98%
form
solid
storage temp.
−20°C
Quality Level
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Application
溴氰菊酯已被用于：
- 通过处理HEK293（人类胚胎肾细胞）Tau-BiFC细胞，研究其作为PP2A/PPP3CA抑制剂的影响
- 研究其对虹鳟鱼的天生免疫力的影响
- 研究其对虎虾斑节对虾分子应激水平的影响
Biochem/physiol Actions
溴氰菊酯是一种 Ⅱ 类型半合成除虫菊酯，其作为钙调磷酸酶（蛋白磷酸酶 2B）的强效抑制剂，IC 50 约为 100 pM。这种抑制作用通过引起非突变钙通道长时间保持开放，允许大量 Ca2+ 进入细胞内，从而导致细胞过度兴奋。一些钠通道突变显示如非洲爪蟾卵母细胞的 L993F 突变，显示出对溴氰菊酯的敏感性降低。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
212.0 °F - closed cup
flash_point_c
100 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Yuhang Hong et al.
Environmental toxicology (2020-08-07)
Pyrethroid pesticides are applied to both agricultural and aquacultural industries for pest control. However, information of their impact on the commercial important freshwater crayfish, Procambarus clarkii is scarce. Therefore, the present study aimed to characterize to effects of a commonly
Jason R Richardson et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1960-1972 (2015-01-30)
Attention-deficit hyperactivity disorder (ADHD) is estimated to affect 8-12% of school-age children worldwide. ADHD is a complex disorder with significant genetic contributions. However, no single gene has been linked to a significant percentage of cases, suggesting that environmental factors may
Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy
Seo JS, et al.
Experimental & Molecular Medicine, 49(5), e333-e333 (2017)
Oxidative stress, protein carbonylation and heat shock proteins in the black tiger shrimp, Penaeus monodon, following exposure to endosulfan and deltamethrin
Dorts J, et al.
Environmental Toxicology and Pharmacology, 28(2), 302-310 (2009)
J Tan et al.
Insect biochemistry and molecular biology, 32(4), 445-454 (2002-03-12)
Pyrethroid insecticides alter the normal gating of voltage-gated sodium channels in the nervous system. Three sodium channel mutations (E434K, C764R, L993F) were recently identified in pyrethroid resistant German cockroach populations. In this report, we show that the L993F mutation decreased
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