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经验公式(希尔记法):
C22H19Br2NO3
化学文摘社编号:
分子量:
505.20
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
258-256-6
Beilstein/REAXYS Number:
6746312
MDL number:
Quality Level
assay
≥98%
form
solid
storage temp.
−20°C
SMILES string
CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2
InChI
1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1
InChI key
OWZREIFADZCYQD-NSHGMRRFSA-N
Application
溴氰菊酯已被用于:
- 通过处理HEK293(人类胚胎肾细胞)Tau-BiFC细胞,研究其作为PP2A/PPP3CA抑制剂的影响
- 研究其对虹鳟鱼的天生免疫力的影响
- 研究其对虎虾斑节对虾分子应激水平的影响
Biochem/physiol Actions
溴氰菊酯是一种 Ⅱ 类型半合成除虫菊酯,其作为钙调磷酸酶(蛋白磷酸酶 2B)的强效抑制剂,IC 50 约为 100 pM。这种抑制作用通过引起非突变钙通道长时间保持开放,允许大量 Ca2+ 进入细胞内,从而导致细胞过度兴奋。一些钠通道突变显示如非洲爪蟾卵母细胞的 L993F 突变,显示出对溴氰菊酯的敏感性降低。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
212.0 °F - closed cup
flash_point_c
100 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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