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D9503

3,4-二羟基- DL- 苯丙氨酸

Name: 3,4-二羟基-<SC> DL-</SC> 苯丙氨酸
Brand: SIGMA

别名:

3-（3,4-二羟基苯基）-DL丙氨酸, DL-3-羟基酪氨酸, DL-DOPA

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关于此项目

线性分子式:

(HO)₂C₆H₃CH₂CH(NH₂)COOH

化学文摘社编号:

63-84-3

分子量:

197.19

NACRES:

NA.32

PubChem Substance ID:

24894298

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-566-0

MDL number:

MFCD00063060

Beilstein/REAXYS Number:

3204800

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Quality Level

100

form

powder

mp

270-272 °C (lit.), 290 °C (dec.) (lit.)

SMILES string

NC(Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)

InChI key

WTDRDQBEARUVNC-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
mouse ... DRD1(13488), DRD2(13489), DRD3(13490), DRD4(13491), DRD5(13492)
rat ... DRD1(24316), DRD2(24318), DRD3(29238), DRD4(25432), DRD5(25195)

Biochem/physiol Actions

3,4-二羟基苯丙氨酸是多巴胺的直接前体，多巴胺是酪氨酸羟化酶的产物。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Dopamine formation, from its immediate precursor 3, 4-dihydroxyphenylalanine, along the rat digestive tract

Vieira-Coelho MA and Soares-da-Silva P

Fundamental & Clinical Pharmacology, 7(5), 235-243 (1993)

Handbook of Developmental Cognitive Neuroscience (2001)

(18)F-FDOPA PET for differentiating recurrent or progressive brain metastatic tumors from late or delayed radiation injury after radiation treatment.

Karlo J Lizarraga et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 30-36 (2013-10-30)

Brain metastases are frequently treated with radiation. It is critical to distinguish recurrent or progressive brain metastases (RPBM) from late or delayed radiation injury (LDRI). The purpose of this study was to examine the diagnostic accuracy as well as the

Production at the Curie level of no-carrier-added 6-18F-fluoro-L-dopa.

Lionel C Libert et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(7), 1154-1161 (2013-05-10)

6-(18)F-fluoro-L-dopa ((18)F-FDOPA) has proven to be a useful radiopharmaceutical for the evaluation of presynaptic dopaminergic function using PET. In comparison to electrophilic synthesis, the no-carrier-added (NCA) nucleophilic method has several advantages. These include much higher available activity and specific activity.

Hydrophobic enhancement of Dopa-mediated adhesion in a mussel foot protein.

Wei Wei et al.

Journal of the American Chemical Society, 135(1), 377-383 (2012-12-12)

Dopa (3,4-dihydroxyphenylalanine) is recognized as a key chemical signature of mussel adhesion and has been adopted into diverse synthetic polymer systems. Dopa's notorious susceptibility to oxidation, however, poses significant challenges to the practical translation of mussel adhesion. Using a surface

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全球贸易项目编号

货号	GTIN
D9503-1G	04061826738467
D9503-5G	04061833590782
D9503-25G	04061833590775

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