D9570
监酸度硫平
≥98% (HPLC)
别名:
3-Dibenzo[b,e]thepin-11(6H)-ylidine-N,N-dimethyl-1-propanamine hydrochloride
InChI key
XUPZAARQDNSRJB-CULRIWENSA-N
InChI
1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥26 mg/mL
storage temp.
room temp
Biochem/physiol Actions
Dothiepin hydrochloride is a tricyclic antidepressant.
C Amey
Journal of affective disorders, 125(1-3), 111-115 (2010-06-24)
Antidepressant-induced switch to mania has not been thoroughly characterized in bipolar disorder and is even less well understood in unipolar depression. I describe, as a first-person narrative, my own experience of psychotic mania, which was suspected to have been induced
H S Kiran et al.
The Journal of the Association of Physicians of India, 58, 120-122 (2010-07-27)
Tricyclic antidepressants (TCAs) may have dangerous cardiac effects in overdose. ECG is useful as both a screening tool for tricyclic antidepressant exposure and as a prognostic indicator. TCA overdose may produce various ECG changes. We report a case of Dothiepin
Case of epirubicin-induced cardiomyopathy in familial cardiomyopathy.
Kate E Shipman et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(18), e537-e538 (2011-04-13)
Delirium as a symptom of tricyclic antidepressant withdrawal.
Jacob Alexander et al.
The Australian and New Zealand journal of psychiatry, 44(9), 863-863 (2010-09-08)
Peter Lepping et al.
Addiction (Abingdon, England), 102(7), 1166-1167 (2007-06-15)
Tricyclic antidepressants sometimes trigger mania in bipolar patients, but little is known about their potential for abuse in this regard. We describe a man with bipolar disorder and alcohol dependency who abused dosulepin repeatedly in order to induce manic episodes.
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