D9571
Dolasetron mesylate hydrate
≥98% (HPLC), powder
别名:
Anzemet hydrate, Dolasetron methanesulfonate hydrate
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关于此项目
经验公式（希尔记法）:
C19H20N2O3 · CH4O3S · xH2O
化学文摘社编号:
分子量:
420.48 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45
InChI
1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;
InChI key
QTFFGPOXNNGTGZ-BHSFMSKKSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: >30 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Dolasetron mesylate hydrate is a highly selective serotonin 5-HT3 receptor antagonist.
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
Features and Benefits
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Swen N Piper et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 36(3), 173-179 (2008-03-21)
The aim of this study was to evaluate the efficacy of dolasetron and droperidol (DHB) for preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery for prognathism. In a randomised, placebo-controlled, double-blind trial, the efficacy of 12.5 mg dolasetron
D Rüsch et al.
Anaesthesia, 62(8), 810-817 (2007-07-20)
It is not known whether dexamethasone increases the effectiveness of anti-emetics when given to treat postoperative nausea and vomiting (PONV). In a randomised study, 242 patients who were experiencing PONV received dolasetron and placebo, haloperidol and placebo, dolasetron and dexamethasone
John A Shields
AANA journal, 76(1), 41-45 (2008-03-08)
Heart block and Q-Tc interval prolongation have been reported with several agents used in anesthesia, and the US Food and Drug Administration mandates evaluation of the Q-T interval with new drugs. Drug-induced Q-T interval prolongation may precipitate life-threatening arrhythmias, is
Laurel M Adams et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 17(9), 1187-1193 (2009-02-12)
The objective of this study was to characterize the impact of casopitant, a novel neurokinin-1 receptor antagonist under investigation for the prevention of postoperative and chemotherapy-induced nausea and vomiting, on the pharmacokinetics of the commonly prescribed 5-hydroxytryptamine receptor 3 receptor
Sadeq A Quraishi et al.
Journal of clinical anesthesia, 23(4), 297-302 (2011-06-15)
To investigate whether a common single nucleotide polymorphism (SNP), rs10494366, is associated with significant prolongation of the QTc interval following administration of 5-HT(3)-receptor antagonists in the perioperative setting. Post-hoc analysis of deoxyribonucleic acid (DNA) samples and electrocardiographic (ECG) data from
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