D9571
Dolasetron mesylate hydrate
≥98% (HPLC), powder
别名:
Anzemet hydrate, Dolasetron methanesulfonate hydrate
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关于此项目
经验公式（希尔记法）:
C19H20N2O3 · CH4O3S · xH2O
化学文摘社编号:
分子量:
420.48 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
H2O: >30 mg/mL
创始人
Sanofi Aventis
储存温度
2-8°C
SMILES字符串
O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45
InChI
1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;
InChI key
QTFFGPOXNNGTGZ-BHSFMSKKSA-N
生化/生理作用
Dolasetron mesylate hydrate is a highly selective serotonin 5-HT3 receptor antagonist.
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.
特点和优势
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
Edward B Silberstein
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(4), 546-549 (2008-03-18)
The goal of this study was to reduce the salivary symptoms of pain and xerostomia caused by 131I therapy for papillary and follicular thyroid carcinoma. In a single-blind controlled prospective study of 60 patients, we investigated whether pilocarpine, 5 mg
Lauren Trepanier
Journal of feline medicine and surgery, 12(3), 225-230 (2010-03-03)
The control of nausea and vomiting in cats is important in order to prevent the development of food aversion, anorexia (with its associated complications of weight loss and dehydration), and hepatic lipidosis. There are several antiemetic drugs that are clinically
Mehdi Hamadani et al.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 13(2), 69-75 (2007-09-18)
The last decade has witnessed the great impact of 5-hydroxytryptamine-3 receptor (5-HT(3))antagonists in revolutionizing the management of platinum-based chemotherapy-induced acute nausea and vomiting (CINV). However, despite the availability of a variety of 5-HT(3) antagonists, little data is published to support
[Pharmacokinetic and pharmacodynamic features of palonosetron].
Armando A Genazzani et al.
Tumori, 94(2), suppl 6-suppl13 (2008-06-21)
商品
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