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Merck
CN

D9667

α-树突毒素

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74504-53-3
UNSPSC Code:
12352200
MDL number:
MFCD00162007

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storage temp.

−20°C

Biochem/physiol Actions

Blocks slowly inactivating outward K+ current; blocks voltage-gated K+-channels in rat brain synaptosomes; increases acetylcholine release at neuromuscular junction.

Other Notes

Isolated initially from Dendroaspis angusticeps (eastern green mamba)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBH1321V
SLBF4729V
SLBF0721V
120M1299
120M1300

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the molecular weight of Product D9667, α-Dendrotoxin?

    Product D9667, α-Dendrotoxin contains 59 residues with a formula weight of 7077 daltons.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

F J Joubert et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(5), 661-674 (1980-05-01)
Toxins C13S1C3 and C13S2C3 from D. angusticeps venom were purified by gel filtration and ion exchange chromatography. Whereas C13S1C3 contains 57 amino acids, C13S2C3 contains 59 but each include six half-cystine residues. The complete primary structure of the low toxicity
S Gasparini et al.
The Journal of biological chemistry, 273(39), 25393-25403 (1998-09-17)
We identified the residues that are important for the binding of alpha-dendrotoxin (alphaDTX) to Kv1 potassium channels on rat brain synaptosomal membranes, using a mutational approach based on site-directed mutagenesis and chemical synthesis. Twenty-six of its 59 residues were individually
K Schmidt et al.
Brain research, 843(1-2), 145-160 (1999-10-21)
Outwardly rectifying K(+) channels determine the membrane conductance and influence the proliferation rate of glial progenitor cells. To analyze the molecular identity and the functional role of K(+) channels in glial progenitors of mouse brain, expression of shaker-type Kv1 genes
Y P Tan et al.
The Journal of physiology, 520 Pt 1, 65-78 (1999-10-12)
1. Action potential-evoked [Ca2+]i rises in basket cell axons of rat cerebellar slices were studied using two-photon laser scanning microscopy and whole-cell recording, to identify the K+ channels controlling the shape of the axonal action potential. 2. Whole-cell recordings of
Seiichiro Jinde et al.
The European journal of neuroscience, 30(6), 1036-1055 (2009-09-09)
Gamma oscillations are a prominent feature of hippocampal network activity, but their functional role remains debated, ranging from mere epiphenomena to being crucial for information processing. Similarly, persistent gamma oscillations sometimes appear prior to epileptic discharges in patients with mesial

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