D9696
Dronedarone hydrochloride
≥98% (HPLC)
别名:
N-{2-Butyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl}methanesulfonamide hydrochloride, Multaq, SR-33589B
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经验公式（希尔记法）:
C31H44N2O5S · HCl
化学文摘社编号:
分子量:
593.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Dronedarone hydrochloride, ≥98% (HPLC)
InChI key
DWKVCQXJYURSIQ-UHFFFAOYSA-N
SMILES string
Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23
InChI
1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: 15 mg/mL, clear
originator
Sanofi Aventis
storage temp.
2-8°C
Quality Level
Gene Information
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Application
Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.
Biochem/physiol Actions
Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation.
Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.
Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Stress degradation studies of dronedarone in pharmaceutical dosage form by a validated stability-indicating LC method
Ahirrao VK, et al.
Journal of the Chilean Chemical Society, 57(3), 1272-1276 (2012)
Use of in vitro morphogenesis of mouse embryoid bodies to assess developmental toxicity of therapeutic drugs contraindicated in pregnancy
Warkus ELL, et al.
Toxicological Sciences, 149(1), 15-30 (2016)
Dronedarone: current evidence and future questions
Schafer JA, et al.
Cardiovascular Therapeutics, 28(1), 38-47 (2010)
Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis
Gunesch AP, et al.
Antimicrobial Agents and Chemotherapy (2020)
Jeremy A Schafer et al.
Cardiovascular therapeutics, 28(1), 38-47 (2010-01-16)
Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting more than 2.2 million Americans. ACC/AHA/ESC guidelines for the management of patients with AF recommend amiodarone for maintaining sinus rhythm. Dronedarone is a derivative of amiodarone indicated for the treatment
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