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Merck
CN

D9815

多沙唑嗪 甲磺酸酯

≥97% (HPLC), powder

别名:

1-（4-氨基-6,7-二甲氧基-2-喹唑啉基）-4-[4-（1,4-苯并二氧基-2-基）carpiperazin-1-基）]-6,7-二甲氧基喹唑啉 甲磺酸酯, 多沙唑嗪甲磺酸盐

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关于此项目

经验公式（希尔记法）:
C23H25N5O5 · CH3SO3H
化学文摘社编号:
77883-43-3
分子量:
547.58
NACRES:
NA.77
PubChem Substance ID:
24278398
UNSPSC Code:
12352200
MDL number:
MFCD00216023
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
200

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产品名称

多沙唑嗪 甲磺酸酯, ≥97% (HPLC), powder

InChI key

VJECBOKJABCYMF-UHFFFAOYSA-N

SMILES string

CS(O)(=O)=O.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4

InChI

1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

assay

≥97% (HPLC)

form

powder

color

white

Quality Level

200

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)

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Biochem/physiol Actions

α1-肾上腺素能受体拮抗剂；放松前列腺平滑肌

Features and Benefits

这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000353455
0000350740
0000350739
0000353455
0000350740

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Thomas F Newton et al.
PloS one, 7(2), e30854-e30854 (2012-02-10)
Preclinical research implicates dopaminergic and noradrenergic mechanisms in mediating the reinforcing effects of drugs of abuse, including cocaine. The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positive
Amy I Lynch et al.
Pharmacogenetics and genomics, 22(5), 355-366 (2012-03-06)
To identify panels of genetic variants that predict treatment-related coronary heart disease (CHD) outcomes in hypertensive patients on one of four different classes of initial antihypertensive treatment. The goal was to identify subgroups of individuals on the basis of their
Giovanni Conzo et al.
International journal of surgery (London, England), 11(2), 152-156 (2012-12-27)
Minimally invasive adrenalectomy for pheochromocytoma (PCC) is a complex surgical procedure especially because of the haemodynamic instability due to the excessive secretion of cathecolamines, which may result in a considerable risk of conversion and complications. By a multicentric retrospective study
Cédric M Hysek et al.
Psychopharmacology, 224(3), 363-376 (2012-06-16)
Pupillometry can be used to characterize autonomic drug effects. This study was conducted to determine the autonomic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), administered alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin, on pupillary function. Infrared pupillometry was
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