D9815
多沙唑嗪 甲磺酸酯
≥97% (HPLC), powder
别名:
1-（4-氨基-6,7-二甲氧基-2-喹唑啉基）-4-[4-（1,4-苯并二氧基-2-基）carpiperazin-1-基）]-6,7-二甲氧基喹唑啉 甲磺酸酯, 多沙唑嗪甲磺酸盐
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关于此项目
经验公式（希尔记法）:
C23H25N5O5 · CH3SO3H
CAS Number:
分子量:
547.58
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white
SMILES字符串
CS(O)(=O)=O.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4
InChI
1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)
InChI key
VJECBOKJABCYMF-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
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生化/生理作用
α1-肾上腺素能受体拮抗剂；放松前列腺平滑肌
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sakip Erturhan et al.
Urology, 81(3), 640-643 (2013-01-25)
To evaluate the possible efficacy of an α1 blocker (doxazosin) therapy on the management and disease course in pediatric patients with distal ureteral stones. A total of 45 patients (24 boys and 21 girls) with a single lower ureteral stone
Cédric M Hysek et al.
Psychopharmacology, 224(3), 363-376 (2012-06-16)
Pupillometry can be used to characterize autonomic drug effects. This study was conducted to determine the autonomic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), administered alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin, on pupillary function. Infrared pupillometry was
Evan Goldfischer et al.
Urology, 79(4), 875-882 (2012-02-22)
To investigate the safety of daily coadministration of α-blockers with tadalafil 5 mg in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. The standard-of-care medical therapy for moderate to severe symptoms of benign prostatic hyperplasia is α(1)-adrenergic
Flávia K Delella et al.
Life sciences, 91(25-26), 1281-1287 (2012-10-17)
To gain new insights into the molecular mechanisms of action of doxazosin, we investigated the prostatic stroma ultrastructure and the expression of genes involved with fibrosis, such as collagen type I and III (COL1A1 and COL3A1, respectively) and TGF-beta 1
Aaron Petty et al.
PloS one, 7(8), e42120-e42120 (2012-08-24)
During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand stimulation, which triggers the intrinsic tumor suppressive signaling pathways of EphA2 including inhibition of
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