form
solid
mp
228-230 °C (lit.)
solubility
ethanol: 3.5 mg/mL (warm), DMSO: soluble
SMILES string
CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3
InChI key
KOVRZNUMIKACTB-UHFFFAOYSA-N
Biochem/physiol Actions
苯二氮卓反向激动剂，可与大脑中苯二氮卓受体的内源性配体密切相关。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
P Skolnick et al.
Psychopathology, 17 Suppl 1, 25-36 (1984-01-01)
The ethyl ester of beta-carboline-3-carboxylic acid (beta-CCE) has a high affinity for benzodiazepine receptors and can antagonize some of the pharmacologic actions of benzodiazepines in rodents. Administration of beta-CCE (2.5 mg/kg) to chair-adapted, male rhesus monkeys (7-9 kg) elicited a
P J Cowen et al.
Nature, 290(5801), 54-55 (1981-03-05)
The mammalian central nervous system possesses specific high-affinity binding sites for the benzodiazepines and considerable evidence suggests that these binding sites are the pharmacological receptors through which these compounds act. Recently, ethyl beta-carboline-3-carboxylate (beta-CCE) has been identified in both human
C Braestrup et al.
Science (New York, N.Y.), 216(4551), 1241-1243 (1982-06-11)
The gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is composed of distinct proteins embedded in the neuronal plasma membrane, is important for several effects of benzodiazepines, including protection afforded against convulsions. During structural modification of ethyl beta-carboline-3-carboxylate an agent was discovered