E006
EDDP 高氯酸盐
Benzodiazepine receptor inverse agonist, solid
别名:
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
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关于此项目
经验公式（希尔记法）:
C13H11N3O
化学文摘社编号:
分子量:
225.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
EDDP 高氯酸盐,
form
solid
Quality Level
color
light tan
solubility
DMSO: >10 mg/mL, H2O: insoluble
SMILES string
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChI key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
Gene Information
human ... BZRAP1(9256)
相关类别
Biochem/physiol Actions
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Disclaimer
Solutions may be stored for several days at 4 °C.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Robert G Mair et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(52), 14293-14300 (2008-12-26)
The rostral intralaminar thalamic nuclei (ILn) are organized to activate pathways originating in medial prefrontal cortex (mPF) that mediate memory-guided responding during alert, wakeful states. Previous studies have shown that rostral ILn or mPF lesions produce deficits in delayed matching
Lotte C Houtepen et al.
Physiology & behavior, 102(1), 105-109 (2010-09-11)
While anxiety models are often based on locomotor activity responses, the stress-induced hyperthermia (SIH) paradigm uses the autonomic stress response by measuring body temperature. The effects of putative anxiogenic compounds in the SIH paradigm are inconclusive in mice and have
Jodi L Lukkes et al.
Physiology & behavior, 107(5), 719-725 (2012-05-16)
Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Therefore, we investigated the effects
Sabrina F Lisboa et al.
The international journal of neuropsychopharmacology, 13(9), 1163-1173 (2010-07-01)
The ventral portion of the medial prefrontal cortex (vMPFC) has been related to the expression of contextual fear conditioning. This study investigated the possible involvement of CB1 receptors in this aversive response. Male Wistar rats were submitted to a contextual
Jee Hyun Kim et al.
Behavioral neuroscience, 123(3), 641-649 (2009-06-03)
A recent finding suggested that when extinction occurs shortly after acquisition, renewal of an extinguished fear response (fear-potentiated startle) to a light conditioned stimulus (CS) is diminished (Myers, Ressler, & Davis, 2006). The present study attempted to extend this finding
商品
DISCOVER Bioactive Small Molecules for Neuroscience
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E006-100MG | 04061832556413 |
| E006-500MG | 04061832556420 |
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