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Merck
CN

E006

Sigma-Aldrich

EDDP 高氯酸盐

Benzodiazepine receptor inverse agonist, solid

别名:

β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide

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关于此项目

经验公式(希尔记法):
C13H11N3O
化学文摘社编号:
分子量:
225.25
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
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产品名称

EDDP 高氯酸盐,

表单

solid

质量水平

颜色

light tan

溶解性

DMSO: >10 mg/mL
H2O: insoluble

SMILES字符串

CNC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

InChI key

QMCOPDWHWYSJSA-UHFFFAOYSA-N

基因信息

human ... BZRAP1(9256)

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生化/生理作用

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

免责声明

Solutions may be stored for several days at 4 °C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Matthew W Hale et al.
Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1285-1293 (2010-07-22)
The basolateral amygdala is a nodal structure within a distributed and interconnected network that regulates anxiety states and anxiety-related behavior. Administration of multiple anxiogenic drugs increases cellular responses (i.e., increases c-Fos expression) in a subregion of the basolateral amygdala, but
Kwok Ho C Choy et al.
Psychopharmacology, 221(4), 649-657 (2011-12-24)
Vigilant scanning of the environment is a major risk assessment activity in many species. However, due to difficulties in its manual scoring, scanning has rarely been quantified in laboratory rodent studies. We developed a novel method for automated measurement of
Jodi L Lukkes et al.
Brain research, 1443, 1-17 (2012-02-03)
Our previous studies have shown that post-weaning social isolation of male rats leads to sensitization of serotonergic systems and increases in anxiety-like behavior in adulthood. Although studies in humans suggest that females have an increased sensitivity to stress and risk
Andrew R Delamater et al.
Journal of experimental psychology. Animal behavior processes, 35(2), 224-237 (2009-04-15)
Previous research has reported a role for the neurotransmitter gamma-aminobutyric acid (GABA) in the extinction and renewal of conditioned fear. Here, the authors examine whether GABA is involved in the acquisition, extinction, renewal, spontaneous recovery, and latent inhibition of appetitive
Sarah I Martire et al.
Behavioural brain research, 209(1), 131-136 (2010-02-02)
Three experiments used intake, clusters, and licks per cluster to study the effects of the GABA inverse agonist, FG 7142, on sensory-specific satiety in rats. In Experiment 1, rats were offered one of two palatable solutions and 30min later tested

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