E006
EDDP 高氯酸盐
Benzodiazepine receptor inverse agonist, solid
别名:
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide
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关于此项目
经验公式（希尔记法）:
C13H11N3O
化学文摘社编号:
分子量:
225.25
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
产品名称
EDDP 高氯酸盐,
表单
solid
质量水平
颜色
light tan
溶解性
DMSO: >10 mg/mL
H2O: insoluble
SMILES字符串
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23
InChI
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)
InChI key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
基因信息
human ... BZRAP1(9256)
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相关类别
生化/生理作用
Benzodiazepine inverse receptor agonist; potent anxiogenic agent.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
免责声明
Solutions may be stored for several days at 4 °C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Lotte C Houtepen et al.
Physiology & behavior, 102(1), 105-109 (2010-09-11)
While anxiety models are often based on locomotor activity responses, the stress-induced hyperthermia (SIH) paradigm uses the autonomic stress response by measuring body temperature. The effects of putative anxiogenic compounds in the SIH paradigm are inconclusive in mice and have
Robert G Mair et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(52), 14293-14300 (2008-12-26)
The rostral intralaminar thalamic nuclei (ILn) are organized to activate pathways originating in medial prefrontal cortex (mPF) that mediate memory-guided responding during alert, wakeful states. Previous studies have shown that rostral ILn or mPF lesions produce deficits in delayed matching
Jee Hyun Kim et al.
Behavioral neuroscience, 123(3), 641-649 (2009-06-03)
A recent finding suggested that when extinction occurs shortly after acquisition, renewal of an extinguished fear response (fear-potentiated startle) to a light conditioned stimulus (CS) is diminished (Myers, Ressler, & Davis, 2006). The present study attempted to extend this finding
Sabrina F Lisboa et al.
The international journal of neuropsychopharmacology, 13(9), 1163-1173 (2010-07-01)
The ventral portion of the medial prefrontal cortex (vMPFC) has been related to the expression of contextual fear conditioning. This study investigated the possible involvement of CB1 receptors in this aversive response. Male Wistar rats were submitted to a contextual
Jodi L Lukkes et al.
Physiology & behavior, 107(5), 719-725 (2012-05-16)
Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Therefore, we investigated the effects
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