E0162
羧基酯酶1异构体c 人
recombinant, expressed in baculovirus infected BTI insect cells
别名:
羧酸酯酶1 人, 羧酸酯酶, 酯酶
Application
人羧酸酯酶 1 亚型 c 已被用作贻贝羧酸酯酶活性的参考标准，用于比较底物特异性和抑制研究。它还被用作商业重组蛋白，用于基于环境化学的抑制研究的方法验证。
Biochem/physiol Actions
羧酸酯酶负责水解含有酯键和酰胺键的药物，例如可卡因和海洛因。它们还水解长链脂肪酸酯和硫酯。羧酸酯酶 1（CE1）催化胆固醇和脂肪酸形成胆固醇酯。通过酯交换反应，CE1 还介导脂肪酸乙酯（FAEE）的产生。它还水解芳族和脂族酯，优先于小的醇基和大的酰基。CE1 代谢药物酯类和酰胺类氨基甲酸酯。它参与环境毒物和致癌物的解毒，并可用于评估前药的药代动力学研究。
General description
羧酸酯酶1（CE1）是大型多基因羧酸酯酶 α,β水解酶家族的成员。它主要在肝脏中表达。CE1 包括一个 αβ 结构域、一个中心催化结构域和一个调控结构域。
该产品的体积为0.5 mL。
Other Notes
一个单位是指在pH 7.4、37℃下，每分钟水解1纳摩尔4-硝基苯基乙酸酯所需的酶量
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Jihong Lian et al.
Protein & cell, 9(2), 178-195 (2017-07-06)
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro
Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
Plasmatic B-esterases as potential biomarkers of exposure to marine plastics in loggerhead turtles.
Sole, et al.
Environmental Research, 213, 113639-113639 (2022)
S Casey Laizure et al.
Pharmacotherapy, 33(2), 210-222 (2013-02-07)
Carboxylesterases are a multigene family of mammalian enzymes widely distributed throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important mediators of drug metabolism. Both are expressed in
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