E0287
羧基酯酶1型b 人
recombinant, expressed in baculovirus infected BTI insect cells
别名:
羧酸酯酶1 人, 羧酸酯酶, 酯酶
登录 查看组织和合同定价。
选择尺寸
变更视图
recombinant
expressed in baculovirus infected BTI insect cells
Quality Level
form
liquid
specific activity
≥500 units/mg protein
concentration
5 mg/mL
weight
(0.5 ml)
shipped in
dry ice
storage temp.
−70°C
General description
羧酸酯酶（CE）属于丝氨酸水解酶家族。它广泛存在于人体中。人体中含有5种羧酸酯酶同工型。它由位于人染色体16q22.2上的CES1基因编码。
羧酸酯酶 1 是大型多基因羧酸酯酶家族的成员之一。这些酶负责水解含有酯和酰胺键的药物，如可卡因和海洛因等。此外，它们还可水解长链脂肪酸酯和硫酯。这种酶可水解芳香酯和脂肪族酯，是细胞胆固醇酯化所必需物质。它还可能在肺解毒和/或保护中枢神经系统免受酯类或酰胺类化合物的伤害方面发挥作用。
Application
人羧酯酶1同工型b被用于将 Amplex red 转化为试卤灵，并且不依赖于辣根过氧化物酶和氧。它还被用于开发发射比率双光子探针（SE1），以用于原位定量。
具有高催化活性，非常适合用于强大的高通量筛选分析，包括药物间相互作用研究以及用于评估前药和非CYP消除途径的药代动力学研究。
Biochem/physiol Actions
羧酸酯酶（CE）与肝脏和肝脂肪变性的药物代谢有关。人体缺乏CE会导致肥胖、高脂血症、胰岛素不敏感和癌症。
Other Notes
一个酶活性单位是指在 pH 7.4、37°C下，每分钟水解1纳摩尔4-硝基苯基乙酸酯所需的酶量
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Non classical monocytes levels, increased by subcutaneous fat-Secretome, are associated with less Rehospitalization after heart failure admission
Eiras S, et al.
Journal of Cardiovascular Translational Research, 10(1), 16-26 (2017)
A carboxylesterase-selective ratiometric fluorescent two-photon probe and its application to hepatocytes and liver tissues
Park SJ, et al.
Chemical Science, 7(6), 3703-3709 (2016)
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays
Miwa S, et al.
Free Radical Biology & Medicine, 90, 173-183 (2016)
B Sànchez-Nogué et al.
Environmental science and pollution research international, 20(5), 3480-3488 (2012-12-06)
The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison
Marie C Fortin et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(2), 326-331 (2012-12-12)
Studies on therapeutic drug disposition in humans have shown significant alterations as the result of pregnancy. However, it is not known whether pesticide metabolic capacity changes throughout pregnancy, which could affect exposure of the developing brain. We sought to determine
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| E0287-1VL | 04061838113603 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持