E0504
依卡林 来源于锯鳞蝰 毒液
prothrombin activator
应用
松鸡 毒液中的 Ecarin 是 Ecarin 凝血时间 (ECT) 试验的主要试剂，用于监测抗凝和凝血酶抑制。它已被用于研究静脉和动脉血栓栓塞的治疗中测试药物的有效性。
Ecarin 活性是 Ecarin 凝固时间 (ECT) 测定的主要依据，用于评估抗血栓作用和凝血酶抑制。
生化/生理作用
凝血酶原激活物
其他说明
在 37℃、pH 8.4 下，一个单位将激活凝血酶原产生一个单位的酰胺分解活性。一个酰胺分解单位将在37°C，pH 8.4下每分钟水解 1.0μmol N-对对甲苯磺酰基-Gly-Pro-Arg-对-硝基苯胺。
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Elise S Eerenberg et al.
Circulation, 124(14), 1573-1579 (2011-09-09)
Rivaroxaban and dabigatran are new oral anticoagulants that specifically inhibit factor Xa and thrombin, respectively. Clinical studies on the prevention and treatment of venous and arterial thromboembolism show promising results. A major disadvantage of these anticoagulants is the absence of
Wei Zhou et al.
Stroke, 42(12), 3594-3599 (2011-10-15)
Dabigatran-etexilate (DE) recently has been approved for stroke prevention in atrial fibrillation. However, lack of effective antagonists represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model
Lambro A Johnson et al.
Analytical biochemistry, 608, 113907-113907 (2020-08-20)
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for thrombin. The coupled reactions result in accelerating p-nitroaniline (pNA) production
Kevin Dietrich et al.
Thrombosis research, 135(4), 630-635 (2015-02-27)
Age-related changes in the hemostatic system result in variation in response to anticoagulants and coagulation assays over childhood. This study used in vitro methods to determine i) optimum coagulation assays for dabigatran in children and ii) anticoagulant effect of dabigatran
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