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E0516

依托度酸

Name: 依托度酸
Brand: SIGMA

别名:

1,8-二乙基-1,3,4,9-四氢吡喃[3,4-b]吲哚-1-乙酸, NSC 282126, 依托度酸

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₁NO₃

化学文摘社编号:

41340-25-4

分子量:

287.35

NACRES:

NA.77

PubChem Substance ID:

24278407

UNSPSC Code:

12352200

MDL number:

MFCD00133313

Quality level:

200

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Quality Level

200

originator

Wyeth

storage temp.

2-8°C

SMILES string

CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12

InChI

1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)

InChI key

NNYBQONXHNTVIJ-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Biochem/physiol Actions

非甾体类抗炎化合物，其是COX-1和COX-2的非选择性抑制剂。

Features and Benefits

该化合物由 Wyeth 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，点击这里。

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000417146

0000404552

0000188584

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Etodolac: the chemistry, pharmacology, metabolic disposition, and clinical profile of a novel anti-inflammatory pyranocarboxylic acid.

L G Humber

Medicinal research reviews, 7(1), 1-28 (1987-01-01)

Etodolac clinical pharmacokinetics.

D R Brocks et al.

Clinical pharmacokinetics, 26(4), 259-274 (1994-04-01)

Etodolac is a chiral nonsteroidal anti-inflammatory drug (NSAID) that is marked as the racemate. Currently, the drug is available in several countries for the treatment of arthritis and the alleviation of pain. Etodolac possesses several unique disposition features mainly due

Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps.

Tetsuji Takayama et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 17(11), 3803-3811 (2011-03-10)

On the basis of the results of our preliminary trial suggesting that aberrant crypt foci (ACF) could be eradicated by short-term administration of sulindac, in the present study, we explored the feasibility of using ACF as surrogate markers for chemoprevention

A review of the antiarthritic efficacy and safety of etodolac.

N Zvaifler

Clinical rheumatology, 8 Suppl 1, 43-53 (1989-03-01)

Etodolac (Lodine, Ramodar, Ultradol), an anti-inflammatory, analgesic agent, is the first of a new class of nonsteroidal anti-inflammatory drugs (NSAIDs), the pyranocarboxylic acids. A review of the literature on numerous clinical studies showed that etodolac (200 to 600 mg/day) is

Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use.

S Lynch et al.

Drugs, 31(4), 288-300 (1986-04-01)

Etodolac is a new non-steroidal agent (NSAID) with anti-inflammatory and analgesic activity. It has been studied in rheumatoid arthritis, osteoarthritis, and pain resulting from minor surgery. In the latter setting, etodolac is at least as effective as aspirin in terms

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全球贸易项目编号

货号	GTIN
E0516-50MG	04061832785356
E0516-10MG	04061833601143

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