E0657
抗-磷酸表皮生长因子受体(pTyr1068)单克隆抗体 小鼠抗
clone 338324, purified immunoglobulin, lyophilized powder
别名:
Monoclonal Anti-EGFR, Monoclonal Anti-ERBB, Monoclonal Anti-HER1, Monoclonal Anti-PIG61
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
338324, monoclonal
Application:
FACS, WB
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
338324, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
flow cytometry: 5 μg/mL, western blot: 1 μg/mL
isotype
IgG2a
UniProt accession no.
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr1068)
Quality Level
Gene Information
human ... EGFR(1956)
相关类别
Immunogen
purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 1068 of human epidermal growth factor receptor.
Biochem/physiol Actions
EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1068 is a minor autophosphorylation site and enables the binding of EGFR to GAB-1 or Grb2.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Fen Wang et al.
Journal of experimental & clinical cancer research : CR, 31, 65-65 (2012-08-21)
EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutation might exist. We hypothesized that activation of phosphorylated
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
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