抗-磷酸表皮生长因子受体(pTyr¹⁰⁶⁸)单克隆抗体 小鼠抗

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 1068 of human epidermal growth factor receptor.

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1068 is a minor autophosphorylation site and enables the binding of EGFR to GAB-1 or Grb2.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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