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经验公式(希尔记法):
C21H36N8O7
化学文摘社编号:
分子量:
512.56
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
EC Number:
257-426-7
Beilstein/REAXYS Number:
873543
产品名称
弹性酶抑制剂, microbial
SMILES string
[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1
InChI
1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1
InChI key
IJWCGVPEDDQUDE-YGJAXBLXSA-N
biological source
microbial
form
powder
solubility
water: 20 mg/mL, clear, faintly yellow to yellow
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
强效不可逆的弹性蛋白酶抑制剂。
强效不可逆的弹性蛋白酶抑制剂。Elastatinal是来自胰腺的弹性蛋白酶的抑制剂比来自白细胞的弹性蛋白酶强得多。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
De-Peng Jiang et al.
Journal of Korean medical science, 26(6), 778-784 (2011-06-10)
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial epithelial 16 (HBE16) cells were pretreated with scutellarin for 60
Sandra Cerqueira Barros et al.
Enzyme and microbial technology, 50(2), 107-114 (2012-01-10)
Elastase plays an important role in wound healing process, degrading damaged tissue and allowing complete tissue recovery. The levels of human neutrophil elastase (HNE) are usually controlled by endogenous inhibitors. However, in the presence of high levels of elastase, like
M M Hardy et al.
The Journal of biological chemistry, 269(28), 18535-18540 (1994-07-15)
In this study, we evaluated the ability of low molecular weight manganese-based superoxide dismutase mimetics to attenuate neutrophil-mediated oxygen radical damage to human aortic endothelial cells in vitro. Human neutrophils, when exposed to tumor necrosis factor-alpha and the complement compound
M K Marschütz et al.
Biomaterials, 21(14), 1499-1507 (2000-06-29)
A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bowman-Birk inhibitor (BBI) and elastatinal, respectively, were
R L Stein et al.
Experientia, 41(5), 638-640 (1985-05-15)
Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis. The trypsin-catalyzed inactivation of leukocyte
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