E0881
弹性酶抑制剂
powder
别名:
(2S)-2-[(4S)-2-氨基-1,4,5,6-四氢-4-嘧啶基]-N-[[[(1S)-1-羧基-3-m甲基丁基]氨基]羰基]甘氨酰基-N1-[(1S)-1-甲基-2-氧代乙基-L-谷氨酰胺
产品名称
弹性酶抑制剂, microbial
生物来源
microbial
质量水平
表单
powder
溶解性
water: 20 mg/mL, clear, faintly yellow to yellow
储存温度
−20°C
SMILES字符串
[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1
InChI
1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1
InChI key
IJWCGVPEDDQUDE-YGJAXBLXSA-N
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生化/生理作用
强效不可逆的弹性蛋白酶抑制剂。
强效不可逆的弹性蛋白酶抑制剂。Elastatinal是来自胰腺的弹性蛋白酶的抑制剂比来自白细胞的弹性蛋白酶强得多。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Valentina Grano et al.
Biotechnology progress, 20(3), 968-974 (2004-06-05)
The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration occurring during hemodialysis or extracorporeal blood circulation in patients undergoing cardiopulmonary bypass. Chemical
T Yagi et al.
Cancer letters, 10(4), 301-307 (1980-10-01)
Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. There were no effects of elastatinal on DNA repair and UV-induced sister chromatid exchanges, and all
R L Stein et al.
Experientia, 41(5), 638-640 (1985-05-15)
Human leukocyte elastase can be proteolytically inactivated by bovine pancreatic trypsin. Neither porcine pancreatic elastase nor bovine pancreatic chymotrypsin causes inactivation of leukocyte elastase, nor are trypsin, pancreatic elastase, or chymotrypsin themselves susceptible to proteolysis. The trypsin-catalyzed inactivation of leukocyte
M K Marschütz et al.
Biomaterials, 21(14), 1499-1507 (2000-06-29)
A drug-carrier matrix has been developed which protects embedded insulin from degradation by the luminally secreted serine-proteases trypsin (EC 3.4.21.4), chymotrypsin (EC 3.4.21.1) and elastase (EC 3.4.21.36) in vitro. Increasing amounts of the Bowman-Birk inhibitor (BBI) and elastatinal, respectively, were
M M Hardy et al.
The Journal of biological chemistry, 269(28), 18535-18540 (1994-07-15)
In this study, we evaluated the ability of low molecular weight manganese-based superoxide dismutase mimetics to attenuate neutrophil-mediated oxygen radical damage to human aortic endothelial cells in vitro. Human neutrophils, when exposed to tumor necrosis factor-alpha and the complement compound
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